The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus
Liver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the factors affecting nonalcoholic steatohepatitis (N...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/7/1487 |
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| author | Chia-Yen Dai Tzu-Jung Fang Wei-Wen Hung Hui-Ju Tsai Yi-Chun Tsai |
| author_facet | Chia-Yen Dai Tzu-Jung Fang Wei-Wen Hung Hui-Ju Tsai Yi-Chun Tsai |
| author_sort | Chia-Yen Dai |
| collection | DOAJ |
| description | Liver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the factors affecting nonalcoholic steatohepatitis (NASH) or liver stiffness also remain unclear. The aim of this study was to evaluate the determinants of liver fibrosis and in T2D patients with NAFLD. Liver fibrosis and steatosis were measured using transient elastography (FibroScan). Of 226 T2D patients with NAFLD, 50 with liver fibrosis had higher body mass index, serum uric acid, triglyceride and glycated hemoglobin levels and lower high density lipoprotein levels than 176 without liver fibrosis. Multivariate analysis revealed that aging, obesity, sulfonylurea usage and high levels of AST increased the risk of liver fibrosis in T2D patients with NAFLD. Our findings provide useful information to clinical physicians for earlier detection of liver fibrosis in T2D patients with NAFLD and to prevent liver fibrosis through controlling these risk factors. |
| first_indexed | 2024-03-09T10:22:12Z |
| format | Article |
| id | doaj.art-601387c997714b82aebdb12740f040e6 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T10:22:12Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-601387c997714b82aebdb12740f040e62023-12-01T21:54:59ZengMDPI AGBiomedicines2227-90592022-06-01107148710.3390/biomedicines10071487The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes MellitusChia-Yen Dai0Tzu-Jung Fang1Wei-Wen Hung2Hui-Ju Tsai3Yi-Chun Tsai4Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDivision of Geriatrics and Gerontology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDivision of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanLiver fibrosis is a key pathophysiology process in chronic liver disease. It is still unclear whether the impact of liver fibrosis is not fully realized in type 2 diabetes mellitus (T2D) patients with nonalcoholic fatty liver disease (NAFLD), and the factors affecting nonalcoholic steatohepatitis (NASH) or liver stiffness also remain unclear. The aim of this study was to evaluate the determinants of liver fibrosis and in T2D patients with NAFLD. Liver fibrosis and steatosis were measured using transient elastography (FibroScan). Of 226 T2D patients with NAFLD, 50 with liver fibrosis had higher body mass index, serum uric acid, triglyceride and glycated hemoglobin levels and lower high density lipoprotein levels than 176 without liver fibrosis. Multivariate analysis revealed that aging, obesity, sulfonylurea usage and high levels of AST increased the risk of liver fibrosis in T2D patients with NAFLD. Our findings provide useful information to clinical physicians for earlier detection of liver fibrosis in T2D patients with NAFLD and to prevent liver fibrosis through controlling these risk factors.https://www.mdpi.com/2227-9059/10/7/1487liver fibrosistype 2 diabetes mellitusNAFLDfibroscan |
| spellingShingle | Chia-Yen Dai Tzu-Jung Fang Wei-Wen Hung Hui-Ju Tsai Yi-Chun Tsai The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus Biomedicines liver fibrosis type 2 diabetes mellitus NAFLD fibroscan |
| title | The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus |
| title_full | The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus |
| title_fullStr | The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus |
| title_short | The Determinants of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus |
| title_sort | determinants of liver fibrosis in patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus |
| topic | liver fibrosis type 2 diabetes mellitus NAFLD fibroscan |
| url | https://www.mdpi.com/2227-9059/10/7/1487 |
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