Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics
ObjectiveWe aim to explore the effects of follicular output rate (FORT) on cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR) in polycystic ovary syndrome (PCOS) patients with different characteristics undergoing in vitro fertilization (IVF) treatment.MethodsThis retrosp...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1079502/full |
| _version_ | 1797980088387502080 |
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| author | Rulan Jiang Mingya Cao Haomeng Hao Rui Jia Rui Jia Peipei Chen Yuanyuan Liu Zhiming Zhao |
| author_facet | Rulan Jiang Mingya Cao Haomeng Hao Rui Jia Rui Jia Peipei Chen Yuanyuan Liu Zhiming Zhao |
| author_sort | Rulan Jiang |
| collection | DOAJ |
| description | ObjectiveWe aim to explore the effects of follicular output rate (FORT) on cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR) in polycystic ovary syndrome (PCOS) patients with different characteristics undergoing in vitro fertilization (IVF) treatment.MethodsThis retrospective study analyzed 454 patients with PCOS undergoing their first IVF cycle at our center from January 2016 to December 2020. FORT was calculated as pre-ovulatory follicle count (PFC) × 100/antral follicle count (AFC). Multivariate regression analyses were conducted to explore the relationships between FORT and CCPR and CLBR. Curve fitting and threshold effect analyses were established to find nonlinear relationships. Effect modification in different subgroups were examined by stratification analyses.ResultsBased on the FORT values, individuals were classified into the following three groups: low-FORT group, middle-FORT group and high-FORT group. Multivariate regression analyses revealed that FORT was an independent factor affecting the CCPR and CLBR significantly (OR = 1.015, 95% CI: 1.001, 1.030 and OR = 1.010, 95% CI:1.001, 1.020). Curve fitting and threshold effect analyses showed that the CCPR and CLBR had a positive correlation with FORT when the FORT was less than 70% (OR = 1.039, 95% CI: 1.013, 1.065 and OR = 1.024, 95% CI: 1.004, 1.044). Stratification analyses showed that the CLBR increased by 1.3% with each additional unit of FORT for patients with hyperandrogenic manifestations (OR = 1.013, 95% CI: 1.001, 1.025). Compared with the low-FORT group, in the high-FORT group, CCPR increased 1.251 times for patients with polycystic ovarian morphology, while CCPR and CLBR increased 1.891 times and 0.99 times for those with ovulation disorder, respectively (OR = 2.251, 95% CI: 1.008, 5.028 and OR = 2.891, 95% CI: 1.332, 6.323 and OR = 1.990, 95% CI: 1.133, 3.494).ConclusionIn patients with PCOS, cumulative IVF outcomes have a positive correlation with FORT when the FORT is less than 70%. For PCOS patients with polycystic ovarian morphology, ovulation disorder or hyperandrogenic manifestations, a high FORT could be conductive to achieving better pregnancy outcomes. |
| first_indexed | 2024-04-11T05:48:48Z |
| format | Article |
| id | doaj.art-601390d8835e4d1b889d9c59fd8f891d |
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| language | English |
| last_indexed | 2024-04-11T05:48:48Z |
| publishDate | 2022-12-01 |
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| spelling | doaj.art-601390d8835e4d1b889d9c59fd8f891d2022-12-22T04:42:07ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10795021079502Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristicsRulan Jiang0Mingya Cao1Haomeng Hao2Rui Jia3Rui Jia4Peipei Chen5Yuanyuan Liu6Zhiming Zhao7Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Urology Hospital, Shenzhen, ChinaDepartment of Gynecology and Obstetrics, Handan First Hospital, Handan, ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaObjectiveWe aim to explore the effects of follicular output rate (FORT) on cumulative clinical pregnancy rate (CCPR) and cumulative live birth rate (CLBR) in polycystic ovary syndrome (PCOS) patients with different characteristics undergoing in vitro fertilization (IVF) treatment.MethodsThis retrospective study analyzed 454 patients with PCOS undergoing their first IVF cycle at our center from January 2016 to December 2020. FORT was calculated as pre-ovulatory follicle count (PFC) × 100/antral follicle count (AFC). Multivariate regression analyses were conducted to explore the relationships between FORT and CCPR and CLBR. Curve fitting and threshold effect analyses were established to find nonlinear relationships. Effect modification in different subgroups were examined by stratification analyses.ResultsBased on the FORT values, individuals were classified into the following three groups: low-FORT group, middle-FORT group and high-FORT group. Multivariate regression analyses revealed that FORT was an independent factor affecting the CCPR and CLBR significantly (OR = 1.015, 95% CI: 1.001, 1.030 and OR = 1.010, 95% CI:1.001, 1.020). Curve fitting and threshold effect analyses showed that the CCPR and CLBR had a positive correlation with FORT when the FORT was less than 70% (OR = 1.039, 95% CI: 1.013, 1.065 and OR = 1.024, 95% CI: 1.004, 1.044). Stratification analyses showed that the CLBR increased by 1.3% with each additional unit of FORT for patients with hyperandrogenic manifestations (OR = 1.013, 95% CI: 1.001, 1.025). Compared with the low-FORT group, in the high-FORT group, CCPR increased 1.251 times for patients with polycystic ovarian morphology, while CCPR and CLBR increased 1.891 times and 0.99 times for those with ovulation disorder, respectively (OR = 2.251, 95% CI: 1.008, 5.028 and OR = 2.891, 95% CI: 1.332, 6.323 and OR = 1.990, 95% CI: 1.133, 3.494).ConclusionIn patients with PCOS, cumulative IVF outcomes have a positive correlation with FORT when the FORT is less than 70%. For PCOS patients with polycystic ovarian morphology, ovulation disorder or hyperandrogenic manifestations, a high FORT could be conductive to achieving better pregnancy outcomes.https://www.frontiersin.org/articles/10.3389/fendo.2022.1079502/fullfollicular output ratecumulative clinical pregnancy ratecumulative live birth ratepolycystic ovarian syndromePCOS characteristicsin vitro fertilization-embryo transfer |
| spellingShingle | Rulan Jiang Mingya Cao Haomeng Hao Rui Jia Rui Jia Peipei Chen Yuanyuan Liu Zhiming Zhao Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics Frontiers in Endocrinology follicular output rate cumulative clinical pregnancy rate cumulative live birth rate polycystic ovarian syndrome PCOS characteristics in vitro fertilization-embryo transfer |
| title | Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics |
| title_full | Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics |
| title_fullStr | Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics |
| title_full_unstemmed | Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics |
| title_short | Effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in PCOS patients with different characteristics |
| title_sort | effects of follicular output rate on cumulative clinical pregnancy rate and cumulative live birth rate in pcos patients with different characteristics |
| topic | follicular output rate cumulative clinical pregnancy rate cumulative live birth rate polycystic ovarian syndrome PCOS characteristics in vitro fertilization-embryo transfer |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1079502/full |
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