Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning
Zearalenone (ZEN) is a mycotoxin produced by <i>Fusarium</i> fungi that contaminates food and feed, affecting both human and animal health. Among farm animals, the pig is a great consumer of grains and has a native sensitivity to mycotoxins. As the main route of contamination is oral, th...
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MDPI AG
2023-07-01
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| Series: | Agriculture |
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| author | Valeria Cristina Bulgaru Ana Maria Pertea Iulian Alexandru Grosu Andrei Cristian Anghel Gina Cecilia Pistol Daniela Eliza Marin Anca Dinischiotu Ionelia Taranu |
| author_facet | Valeria Cristina Bulgaru Ana Maria Pertea Iulian Alexandru Grosu Andrei Cristian Anghel Gina Cecilia Pistol Daniela Eliza Marin Anca Dinischiotu Ionelia Taranu |
| author_sort | Valeria Cristina Bulgaru |
| collection | DOAJ |
| description | Zearalenone (ZEN) is a mycotoxin produced by <i>Fusarium</i> fungi that contaminates food and feed, affecting both human and animal health. Among farm animals, the pig is a great consumer of grains and has a native sensitivity to mycotoxins. As the main route of contamination is oral, the intestine is the first defense barrier that plays an important role in the immune response being able to secrete effector molecules (cytokines). At the European level, there are no regulations regarding the amount of ZEN that can be present in the feed of piglets, only recommendations for piglets 0.100 mg ZEN/kg feed (100 ppb). In this study, the effects of ZEN in concentrations below (75 ppb) and above (290 ppb) EU recommendation on the level of some key markers involved in the oxidative and inflammatory response, as well as the mechanisms and signaling pathways through which ZEN could produce its toxicity, were monitored in the colon of weaned piglets. The exposure of the piglets to the lower concentration of ZEN (75 ppb) did not lead to changes in stress and inflammation markers or in the signaling pathways associated with these processes. |
| first_indexed | 2024-03-11T01:24:27Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0472 |
| language | English |
| last_indexed | 2024-03-11T01:24:27Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
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| series | Agriculture |
| spelling | doaj.art-601687e771154ad7b7fe9759689428b92023-11-18T17:52:54ZengMDPI AGAgriculture2077-04722023-07-01137137210.3390/agriculture13071372Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after WeaningValeria Cristina Bulgaru0Ana Maria Pertea1Iulian Alexandru Grosu2Andrei Cristian Anghel3Gina Cecilia Pistol4Daniela Eliza Marin5Anca Dinischiotu6Ionelia Taranu7Laboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaLaboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaLaboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaLaboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaLaboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaLaboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaFaculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, RomaniaLaboratory of Animal Biology, National Institute of Research and Development for Biology and Animal Nutrition, 077015 Balotesti, RomaniaZearalenone (ZEN) is a mycotoxin produced by <i>Fusarium</i> fungi that contaminates food and feed, affecting both human and animal health. Among farm animals, the pig is a great consumer of grains and has a native sensitivity to mycotoxins. As the main route of contamination is oral, the intestine is the first defense barrier that plays an important role in the immune response being able to secrete effector molecules (cytokines). At the European level, there are no regulations regarding the amount of ZEN that can be present in the feed of piglets, only recommendations for piglets 0.100 mg ZEN/kg feed (100 ppb). In this study, the effects of ZEN in concentrations below (75 ppb) and above (290 ppb) EU recommendation on the level of some key markers involved in the oxidative and inflammatory response, as well as the mechanisms and signaling pathways through which ZEN could produce its toxicity, were monitored in the colon of weaned piglets. The exposure of the piglets to the lower concentration of ZEN (75 ppb) did not lead to changes in stress and inflammation markers or in the signaling pathways associated with these processes.https://www.mdpi.com/2077-0472/13/7/1372zearalenonepigletsweaninginflammationoxidative stresssignaling pathway |
| spellingShingle | Valeria Cristina Bulgaru Ana Maria Pertea Iulian Alexandru Grosu Andrei Cristian Anghel Gina Cecilia Pistol Daniela Eliza Marin Anca Dinischiotu Ionelia Taranu Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning Agriculture zearalenone piglets weaning inflammation oxidative stress signaling pathway |
| title | Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning |
| title_full | Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning |
| title_fullStr | Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning |
| title_full_unstemmed | Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning |
| title_short | Effects and Underlying Mechanisms of Zearalenone Mycotoxin at Concentrations Close to the EC Recommendation on the Colon of Piglets after Weaning |
| title_sort | effects and underlying mechanisms of zearalenone mycotoxin at concentrations close to the ec recommendation on the colon of piglets after weaning |
| topic | zearalenone piglets weaning inflammation oxidative stress signaling pathway |
| url | https://www.mdpi.com/2077-0472/13/7/1372 |
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