Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats

Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats

Inflammation-mediated alterations in glutamate neurotransmission constitute the most important pathway in the pathophysiology of various brain disorders. The excessive signalling of glutamate results in excitotoxicity, neuronal degeneration, and neuronal cell death. In the present study, we investig...

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Bibliographic Details
Main Authors: Sibi P Ittiyavirah, Kannan Ramalingam, Arathy Sathyan, R.S. Rajasree, Mohamed Saheer Kuruniyan, Syed Altafuddin Quadri, Muhammed Elayadeth-Meethal, Punnoth Poonkuzhi Naseef
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Black cumin
Excitotoxicity
Ibotenic acid
Neuroinflammation
Nigella sativa
Thymoquinone
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016422002559

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