Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development

Thymic epithelial cells (TEC) effect crucial roles in thymopoiesis including the control of negative thymocyte selection. This process depends on their capacity to express promiscuously genes encoding tissue-restricted antigens. This competence is accomplished in medullary TEC (mTEC) in part by the...

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Bibliographic Details
Main Authors: Adam E. Handel, Noriko Shikama-Dorn, Saule Zhanybekova, Stefano Maio, Annina N. Graedel, Saulius Zuklys, Chris P. Ponting, Georg A. Holländer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
chromatin immunoprecipitation
histone modifications
thymic epithelial cells
AIRE
tissue restricted antigen
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02120/full

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