REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL
Objective: To find out the rate of remission of Pre-B Acute Lymphoblastic Leukaemia in children at the end of induction treatment with United Kingdom Acute Lymphoblastic Leukaemia (UKALL) 2011 chemotherapy protocol. Study Design: Prospective observational study. Place and Duration of Study: Pa...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2021-04-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/2966 |
| _version_ | 1818852269187137536 |
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| author | Hafiz Muhammad Murtaza Tariq Ghafoor Muhammad Shaheen Iqbal |
| author_facet | Hafiz Muhammad Murtaza Tariq Ghafoor Muhammad Shaheen Iqbal |
| author_sort | Hafiz Muhammad Murtaza |
| collection | DOAJ |
| description | Objective: To find out the rate of remission of Pre-B Acute Lymphoblastic Leukaemia in children at the end of induction treatment with United Kingdom Acute Lymphoblastic Leukaemia (UKALL) 2011 chemotherapy protocol.
Study Design: Prospective observational study.
Place and Duration of Study: Paediatric Oncology Unit, Combined Military Hospital Rawalpindi, from Nov 2017 to Oct 2018.
Methodology: Data of newly diagnosed patients of Pre-B Acute lymphoblastic Leukaemia, between 1 and 15 years of age was analysed. Patients were divided into low and high-risk groups and treated with United Kingdom Acute Lymphoblastic Leukaemia 2011 induction chemotherapy on regimens A and B respectively. Bone marrow aspiration was performed at the end of induction therapy (28 days), to document their remission status. Patients having ≤5% of blast cells were categorized to be in remission state and those with >5% blast cells were not considered in a state of remission.
Results: A total of 79 patients, 45 (57%) male and 34 (43%) females were enrolled. The mean age was 5.79 ± 3.59 years. Fever (86.1%) and pallor (77.2%) were the most common presentations. Fifty-three (67.1%) patients were treated with regimen A and 26 (32.9%) had regimen B chemotherapy. Febrile neutropenia and myopathy were the most common complications seen in 73 (92.4%) and 54 (71.1%) patients respectively. Eight patients (10.1%) died during induction chemotherapy. Bone marrow aspiration done at the end showed a 100% rate of remission for both regimens A and B.
Conclusion: Risk-based treatment of paediatric Acute lymphoblastic Leukaemia............ |
| first_indexed | 2024-12-19T07:18:14Z |
| format | Article |
| id | doaj.art-6017fa56f59f4f739266757055a01153 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-19T07:18:14Z |
| publishDate | 2021-04-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-6017fa56f59f4f739266757055a011532022-12-21T20:31:01ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-04-017124697210.51253/pafmj.v71i2.29662966REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOLHafiz Muhammad Murtaza0Tariq Ghafoor1Muhammad Shaheen Iqbal2Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Bone Marrow Transplantation/National University of Medical Sciences (NUMS) Rawalpindi PakistanPakistan Council of Scientific and Industrial Research, Islamabad PakistanObjective: To find out the rate of remission of Pre-B Acute Lymphoblastic Leukaemia in children at the end of induction treatment with United Kingdom Acute Lymphoblastic Leukaemia (UKALL) 2011 chemotherapy protocol. Study Design: Prospective observational study. Place and Duration of Study: Paediatric Oncology Unit, Combined Military Hospital Rawalpindi, from Nov 2017 to Oct 2018. Methodology: Data of newly diagnosed patients of Pre-B Acute lymphoblastic Leukaemia, between 1 and 15 years of age was analysed. Patients were divided into low and high-risk groups and treated with United Kingdom Acute Lymphoblastic Leukaemia 2011 induction chemotherapy on regimens A and B respectively. Bone marrow aspiration was performed at the end of induction therapy (28 days), to document their remission status. Patients having ≤5% of blast cells were categorized to be in remission state and those with >5% blast cells were not considered in a state of remission. Results: A total of 79 patients, 45 (57%) male and 34 (43%) females were enrolled. The mean age was 5.79 ± 3.59 years. Fever (86.1%) and pallor (77.2%) were the most common presentations. Fifty-three (67.1%) patients were treated with regimen A and 26 (32.9%) had regimen B chemotherapy. Febrile neutropenia and myopathy were the most common complications seen in 73 (92.4%) and 54 (71.1%) patients respectively. Eight patients (10.1%) died during induction chemotherapy. Bone marrow aspiration done at the end showed a 100% rate of remission for both regimens A and B. Conclusion: Risk-based treatment of paediatric Acute lymphoblastic Leukaemia............https://pafmj.org/index.php/PAFMJ/article/view/2966acute lymphoblastic leukaemiainduction chemotherapypre-b acute lymphoblastic leukaemiaremission rateunited kingdom acute lymphoblastic leukaemia |
| spellingShingle | Hafiz Muhammad Murtaza Tariq Ghafoor Muhammad Shaheen Iqbal REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL Pakistan Armed Forces Medical Journal acute lymphoblastic leukaemia induction chemotherapy pre-b acute lymphoblastic leukaemia remission rate united kingdom acute lymphoblastic leukaemia |
| title | REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL |
| title_full | REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL |
| title_fullStr | REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL |
| title_full_unstemmed | REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL |
| title_short | REMISSION RATE OF PRE-B ALL (ACUTE LYMPHOBLASTIC LEUKEMIA) AFTER INDUCTION CHEMOTHERAPY FOLLOWING UNITED KINGDOM ACUTE LYMPHOBLASTIC LEUKAEMIA 2011 (UKALL 2011) TRIAL PROTOCOL |
| title_sort | remission rate of pre b all acute lymphoblastic leukemia after induction chemotherapy following united kingdom acute lymphoblastic leukaemia 2011 ukall 2011 trial protocol |
| topic | acute lymphoblastic leukaemia induction chemotherapy pre-b acute lymphoblastic leukaemia remission rate united kingdom acute lymphoblastic leukaemia |
| url | https://pafmj.org/index.php/PAFMJ/article/view/2966 |
| work_keys_str_mv | AT hafizmuhammadmurtaza remissionrateofpreballacutelymphoblasticleukemiaafterinductionchemotherapyfollowingunitedkingdomacutelymphoblasticleukaemia2011ukall2011trialprotocol AT tariqghafoor remissionrateofpreballacutelymphoblasticleukemiaafterinductionchemotherapyfollowingunitedkingdomacutelymphoblasticleukaemia2011ukall2011trialprotocol AT muhammadshaheeniqbal remissionrateofpreballacutelymphoblasticleukemiaafterinductionchemotherapyfollowingunitedkingdomacutelymphoblasticleukaemia2011ukall2011trialprotocol |