| Summary: | Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is one of the important reactive oxygen species (ROS), which is closely related to many pathological and physiological processes in living organisms. Excessive H<sub>2</sub>O<sub>2</sub> can lead to cancer, diabetes, cardiovascular diseases, and other diseases, so it is necessary to detect H<sub>2</sub>O<sub>2</sub> in living cells. Since this work designed a novel fluorescent probe to detect the concentration of H<sub>2</sub>O<sub>2</sub>, the H<sub>2</sub>O<sub>2</sub> reaction group arylboric acid was attached to the fluorescein 3-Acetyl-7-hydroxycoumarin as a specific recognition group for the selective detection of hydrogen peroxide. The experimental results show that the probe can effectively detect H<sub>2</sub>O<sub>2</sub> with high selectivity and measure cellular ROS levels. Therefore, this novel fluorescent probe provides a potential monitoring tool for a variety of diseases caused by H<sub>2</sub>O<sub>2</sub> excess.
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