Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway

Combination of Ruthenium Complex and Doxorubicin Synergistically Inhibits Cancer Cell Growth by Down-Regulating PI3K/AKT Signaling Pathway

Combinational use of drugs has been a common strategy in cancer treatment because of synergistic advantages in reducing dose and toxicity, minimizing or delaying drug resistance. To improve the efficacy of chemotherapy, various potential combinations have been investigated. Ruthenium complex is cons...

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Bibliographic Details
Main Authors: Ke Lin, Yi Rong, Dan Chen, Zizhuo Zhao, Huaben Bo, Aimin Qiao, Xiaojuan Hao, Jinquan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
ruthenium complex
doxorubicin
combination therapy
synergistic effect
PI3K/AKT signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00141/full

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