Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib <i>in vitro</i> by altering cell bioenergetics

Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib <i>in vitro</i> by altering cell bioenergetics

<b>Objective</b> Despite recent advancements in targeted therapy and immunotherapies, prognosis for metastatic melanoma patients remains extremely poor. Development of resistance to previously effective treatments presents a serious challenge and new approaches for melanoma treatment are...

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Bibliographic Details
Main Authors: Jelena Grahovac, Tatjana Srdi?-Raji?, Juan Francisco Santiba?ez, Marijana Pavlovi?, Milena ?avi?, Sini?a Radulovi?
Format: Article
Language:English
Published: China Anti-Cancer Association 2019-06-01
Series:Cancer Biology & Medicine
Subjects:
Melanoma
telmisartan
apoptosis
mitochondria
reactive oxygen species
targeted therapy
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1420

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