Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils

Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils

IntroductionGranulomatosis with polyangiitis (GPA) is a small vessel vasculitis with a complex pathomechanism. Organ damage in GPA is also mediated by extracellular trap formation (NETosis). We analyzed the functional status of phosphoproteins modulating NETosis in neutrophils by the mammalian targe...

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Bibliographic Details
Main Authors: Marcin Surmiak, Katarzyna Wawrzycka-Adamczyk, Joanna Kosałka-Węgiel, Anna Włudarczyk, Marek Sanak, Jacek Musiał
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
granulomatosis with polyangiitis
mammalian target of rapamycin
neutrophil extracellular traps
autophagy
neutrophils
mitochondrial DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1227369/full

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