Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes
This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/11/1134 |
| _version_ | 1797464558248394752 |
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| author | Mansor Fazliana Zubaidah Nor Hanipah |
| author_facet | Mansor Fazliana Zubaidah Nor Hanipah |
| author_sort | Mansor Fazliana |
| collection | DOAJ |
| description | This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk. |
| first_indexed | 2024-03-09T18:08:51Z |
| format | Article |
| id | doaj.art-601dd59deb7a45e882bdfdddc3fce7ec |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T18:08:51Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-601dd59deb7a45e882bdfdddc3fce7ec2023-11-24T09:13:35ZengMDPI AGMetabolites2218-19892022-11-011211113410.3390/metabo12111134Mechanisms and Outcomes of Metabolic Surgery in Type 2 DiabetesMansor Fazliana0Zubaidah Nor Hanipah1Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Selangor 40170, MalaysiaDepartment of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaThis review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk.https://www.mdpi.com/2218-1989/12/11/1134diabetesbariatric surgerymetabolic surgeryendocrinemicroRNAgut microbiota |
| spellingShingle | Mansor Fazliana Zubaidah Nor Hanipah Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes Metabolites diabetes bariatric surgery metabolic surgery endocrine microRNA gut microbiota |
| title | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
| title_full | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
| title_fullStr | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
| title_full_unstemmed | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
| title_short | Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes |
| title_sort | mechanisms and outcomes of metabolic surgery in type 2 diabetes |
| topic | diabetes bariatric surgery metabolic surgery endocrine microRNA gut microbiota |
| url | https://www.mdpi.com/2218-1989/12/11/1134 |
| work_keys_str_mv | AT mansorfazliana mechanismsandoutcomesofmetabolicsurgeryintype2diabetes AT zubaidahnorhanipah mechanismsandoutcomesofmetabolicsurgeryintype2diabetes |