A mRNA Vaccine for Crimean–Congo Hemorrhagic Fever Virus Expressing Non-Fusion GnGc Using NSm Linker Elicits Unexpected Immune Responses in Mice

A mRNA Vaccine for Crimean–Congo Hemorrhagic Fever Virus Expressing Non-Fusion GnGc Using NSm Linker Elicits Unexpected Immune Responses in Mice

Crimean–Congo hemorrhagic fever (CCHF), caused by Crimean–Congo Hemorrhagic virus (CCHFV), is listed in the World Health Organization’s list of priority diseases. The high fatality rate in humans, the widespread distribution of CCHFV, and the lack of approved specific vaccines are the primary concer...

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Bibliographic Details
Main Authors: Tong Chen, Zhe Ding, Xuejie Li, Yingwen Li, Jiaming Lan, Gary Wong
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Viruses
Subjects:
Crimean–Congo hemorrhagic fever virus
NSm
Gn
Gc
mRNA vaccine
LNPs
Online Access:https://www.mdpi.com/1999-4915/16/3/378

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