Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer
Background and objective It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2012-07-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.07.02 |
| _version_ | 1819206038185836544 |
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| author | Xingsheng HU Xi FU Shimin WEN Xinyi ZOU Yusong LIU |
| author_facet | Xingsheng HU Xi FU Shimin WEN Xinyi ZOU Yusong LIU |
| author_sort | Xingsheng HU |
| collection | DOAJ |
| description | Background and objective It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC). Methods MACC1 and c-met expressions were detected in 103 cases of NSCLC and 40 cases of neighboring normal lung cancer tissue using immunohistochemistry. Results MACC1 and c-met expressions were significantly higher in lung cancer tissues than that in neighboring normal tissue (P<0.001). MACC1 and c-met expressions were associated with poor differentiation, advanced T stages, lymph node metastasis, and advanced TNM stages (P<0.05) of NSCLC, but not with sex, age, smoking, and histological classification (P>0.05). In addition, a positive correlation between MACC1 and c-met expressions was observed (r=0.403, P<0.001). The result from the Kaplan-Meier survival analysis showed that the five-year survival rate in patients with positive MACC1 and c-met expressions was remarkanly lower than that in patients with negative expressions (P<0.05). The result from the Cox regression analysis showed that MACC1 expression was an independent prognostic factor for NSCLC (P=0.026). Conclusion MACC1 and c-met have an important function in the differentiation, invasion, and metastasis of NSCLC. MACC1 and c-met have poor prognosis in patients with NSCLC. Moreover, MACC1 expression is an independent prognostic factor for NSCLC. |
| first_indexed | 2024-12-23T05:01:14Z |
| format | Article |
| id | doaj.art-601f374b7d3c49a495f7ae4cb395d648 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-23T05:01:14Z |
| publishDate | 2012-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-601f374b7d3c49a495f7ae4cb395d6482022-12-21T17:59:13ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872012-07-0115739940310.3779/j.issn.1009-3419.2012.07.02Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung CancerXingsheng HUXi FUShimin WENXinyi ZOUYusong LIUBackground and objective It has been proven that metastasis-associated in colon cancer 1 (MACC1) is a new gene that is related to the invasion and metastasis of tumors. MACC1 also regulates c-met expression. The aim of this study is to explore the expressions of MACC1 and hepatocyte growth factor receptor (c-met), and its relationship with invasion, metastasis, and prognosis of non-small cell lung cancer (NSCLC). Methods MACC1 and c-met expressions were detected in 103 cases of NSCLC and 40 cases of neighboring normal lung cancer tissue using immunohistochemistry. Results MACC1 and c-met expressions were significantly higher in lung cancer tissues than that in neighboring normal tissue (P<0.001). MACC1 and c-met expressions were associated with poor differentiation, advanced T stages, lymph node metastasis, and advanced TNM stages (P<0.05) of NSCLC, but not with sex, age, smoking, and histological classification (P>0.05). In addition, a positive correlation between MACC1 and c-met expressions was observed (r=0.403, P<0.001). The result from the Kaplan-Meier survival analysis showed that the five-year survival rate in patients with positive MACC1 and c-met expressions was remarkanly lower than that in patients with negative expressions (P<0.05). The result from the Cox regression analysis showed that MACC1 expression was an independent prognostic factor for NSCLC (P=0.026). Conclusion MACC1 and c-met have an important function in the differentiation, invasion, and metastasis of NSCLC. MACC1 and c-met have poor prognosis in patients with NSCLC. Moreover, MACC1 expression is an independent prognostic factor for NSCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2012.07.02Lung neoplasmsMACC1c-metInvasionMetastasisPrognosis |
| spellingShingle | Xingsheng HU Xi FU Shimin WEN Xinyi ZOU Yusong LIU Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms MACC1 c-met Invasion Metastasis Prognosis |
| title | Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer |
| title_full | Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer |
| title_fullStr | Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer |
| title_full_unstemmed | Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer |
| title_short | Prognostic Value of MACC1 and c-met Expressions in Non-small Cell Lung Cancer |
| title_sort | prognostic value of macc1 and c met expressions in non small cell lung cancer |
| topic | Lung neoplasms MACC1 c-met Invasion Metastasis Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.07.02 |
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