Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis
Methods:The prevalence of multiple sclerosis (MS) is high in patients suffering from 25-hydroxyvitamin D3 [25(OH)D] deficiency. The aim of this study was to investigate the possible association of saliva and serum 25(OH)D concentrations with MS in women. Methods: Serum and saliva 25(OH)D levels of 3...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2020-03-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_90613_c265edcb66032ed98856148a55e5dbe2.pdf |
| _version_ | 1797790756155424768 |
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| author | Mohammad-Reza Mirzaii-Dizgah Mohammad-Hosein Mirzaii-Dizgah Iraj Mirzaii-Dizgah |
| author_facet | Mohammad-Reza Mirzaii-Dizgah Mohammad-Hosein Mirzaii-Dizgah Iraj Mirzaii-Dizgah |
| author_sort | Mohammad-Reza Mirzaii-Dizgah |
| collection | DOAJ |
| description | Methods:The prevalence of multiple sclerosis (MS) is high in patients suffering from 25-hydroxyvitamin D3 [25(OH)D] deficiency. The aim of this study was to investigate the possible association of saliva and serum 25(OH)D concentrations with MS in women. Methods: Serum and saliva 25(OH)D levels of 30 MS women and 30 matched healthy controls in this case-control study were measured by ELISA. Data were analyzed by unpaired two-tailed student’s t-test, Pearson correlation test and Receiver operating characteristic (ROC). Results: The mean levels of 25(OH)D in serum and in both stimulated and unstimulated saliva were significantly lower in patients with MS. Serum levels of 25(OH) significantly correlated with stimulated (r = 0.575; P=0.003) and unstimulated saliva (r = 0.548; P=0.004). The mean (±SD) EDSS was 3.6±1.9 in the MS group. EDSS was not significantly correlated with 25(OH)D in serum or in stimulated and unstimulated saliva. The cut-off points of 25(OH)D in serum and saliva were 18 ng/ml and 65 pg/ml, respectively. Conclusions:25(OH)D level in saliva like in serum was low in MS women. Serum 25(OH)D levels correlated positively with saliva 25(OH)D in women suffering from MS. |
| first_indexed | 2024-03-13T02:09:04Z |
| format | Article |
| id | doaj.art-601f858a8572462085a6bd203f087cd0 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:09:04Z |
| publishDate | 2020-03-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-601f858a8572462085a6bd203f087cd02023-07-01T05:15:06ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432020-03-0127210611210.22062/jkmu.2020.9061390613Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple SclerosisMohammad-Reza Mirzaii-Dizgah0Mohammad-Hosein Mirzaii-Dizgah1Iraj Mirzaii-Dizgah2Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, IranStudent Research Committee, School of Dentistry, Aja University of Medical Sciences; Tehran, IranProfessor Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, IranMethods:The prevalence of multiple sclerosis (MS) is high in patients suffering from 25-hydroxyvitamin D3 [25(OH)D] deficiency. The aim of this study was to investigate the possible association of saliva and serum 25(OH)D concentrations with MS in women. Methods: Serum and saliva 25(OH)D levels of 30 MS women and 30 matched healthy controls in this case-control study were measured by ELISA. Data were analyzed by unpaired two-tailed student’s t-test, Pearson correlation test and Receiver operating characteristic (ROC). Results: The mean levels of 25(OH)D in serum and in both stimulated and unstimulated saliva were significantly lower in patients with MS. Serum levels of 25(OH) significantly correlated with stimulated (r = 0.575; P=0.003) and unstimulated saliva (r = 0.548; P=0.004). The mean (±SD) EDSS was 3.6±1.9 in the MS group. EDSS was not significantly correlated with 25(OH)D in serum or in stimulated and unstimulated saliva. The cut-off points of 25(OH)D in serum and saliva were 18 ng/ml and 65 pg/ml, respectively. Conclusions:25(OH)D level in saliva like in serum was low in MS women. Serum 25(OH)D levels correlated positively with saliva 25(OH)D in women suffering from MS.https://jkmu.kmu.ac.ir/article_90613_c265edcb66032ed98856148a55e5dbe2.pdfmultiple sclerosis 25hydroxycholecalciferol saliva |
| spellingShingle | Mohammad-Reza Mirzaii-Dizgah Mohammad-Hosein Mirzaii-Dizgah Iraj Mirzaii-Dizgah Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis Journal of Kerman University of Medical Sciences multiple sclerosis 25 hydroxycholecalciferol saliva |
| title | Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis |
| title_full | Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis |
| title_fullStr | Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis |
| title_full_unstemmed | Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis |
| title_short | Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis |
| title_sort | reduction of saliva and serum 25 hydroxycholecalciferol in multiple sclerosis |
| topic | multiple sclerosis 25 hydroxycholecalciferol saliva |
| url | https://jkmu.kmu.ac.ir/article_90613_c265edcb66032ed98856148a55e5dbe2.pdf |
| work_keys_str_mv | AT mohammadrezamirzaiidizgah reductionofsalivaandserum25hydroxycholecalciferolinmultiplesclerosis AT mohammadhoseinmirzaiidizgah reductionofsalivaandserum25hydroxycholecalciferolinmultiplesclerosis AT irajmirzaiidizgah reductionofsalivaandserum25hydroxycholecalciferolinmultiplesclerosis |