A Splice Site Variant of CDK12 and Breast Cancer in Three Eurasian Populations

A Splice Site Variant of CDK12 and Breast Cancer in Three Eurasian Populations

CDK12 is a member of the cyclin-dependent kinase family that acts as regulator of DNA damage response gene expression. A c.1047-2A>G splice site variant of the CDK12 gene was recently reported to strongly associate with hereditary breast and ovarian cancer in patients of Tatar ethnic origin....

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Bibliographic Details
Main Authors: Natalia V. Bogdanova, Peter Schürmann, Yana Valova, Natalia Dubrowinskaja, Nurzhan Turmanov, Tatyana Yugay, Zura Essimsiitova, Elvira Mingazheva, Darya Prokofyeva, Marina Bermisheva, Elza Khusnutdinova, Thilo Dörk
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Oncology
Subjects:
breast carcinoma
genetic susceptibility
DNA double-strand break repair
chromosome breakage syndrome
founder mutation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00493/full

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