Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population.
OBJECTIVE: Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3655942?pdf=render |
| _version_ | 1819054080675282944 |
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| author | Di Hu Guohua Hu Jing Zhu Yang Shen Houyong Kang Suling Hong |
| author_facet | Di Hu Guohua Hu Jing Zhu Yang Shen Houyong Kang Suling Hong |
| author_sort | Di Hu |
| collection | DOAJ |
| description | OBJECTIVE: Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in the Chinese Han population. METHODS: We included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP). RESULTS: A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (P<0.001). In addition, substantially high frequencies of the GGCA and GGCG haplotypes were observed in the AR patients, unlike that observed in the control individuals (P<0.05). The results suggest that the AGTG haplotype may provide protection against AR (P<0.001). CONCLUSIONS: To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Chinese Han population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified. |
| first_indexed | 2024-12-21T12:45:56Z |
| format | Article |
| id | doaj.art-6026b7f23cf445c28b9b7f2ed7329f50 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T12:45:56Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6026b7f23cf445c28b9b7f2ed7329f502022-12-21T19:03:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6385810.1371/journal.pone.0063858Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population.Di HuGuohua HuJing ZhuYang ShenHouyong KangSuling HongOBJECTIVE: Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in the Chinese Han population. METHODS: We included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP). RESULTS: A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (P<0.001). In addition, substantially high frequencies of the GGCA and GGCG haplotypes were observed in the AR patients, unlike that observed in the control individuals (P<0.05). The results suggest that the AGTG haplotype may provide protection against AR (P<0.001). CONCLUSIONS: To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Chinese Han population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified.http://europepmc.org/articles/PMC3655942?pdf=render |
| spellingShingle | Di Hu Guohua Hu Jing Zhu Yang Shen Houyong Kang Suling Hong Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. PLoS ONE |
| title | Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. |
| title_full | Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. |
| title_fullStr | Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. |
| title_full_unstemmed | Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. |
| title_short | Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. |
| title_sort | association between polymorphisms of the il 23r gene and allergic rhinitis in a chinese han population |
| url | http://europepmc.org/articles/PMC3655942?pdf=render |
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