Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
ABSTRACT Objective: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. Subjects and methods: Twenty-five patien...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2020-08-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600758&tlng=en |
| _version_ | 1828133417871474688 |
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| author | Rodrigo de Azeredo Siqueira Aluana Santana Carlos Joana Costa d'Avila Adalgiza Mafra Moreno Estela Luz Alves Maria Lucia Fleiuss de Farias Laura Maria C. Mendonça Marilia Martins Guimarães |
| author_facet | Rodrigo de Azeredo Siqueira Aluana Santana Carlos Joana Costa d'Avila Adalgiza Mafra Moreno Estela Luz Alves Maria Lucia Fleiuss de Farias Laura Maria C. Mendonça Marilia Martins Guimarães |
| author_sort | Rodrigo de Azeredo Siqueira |
| collection | DOAJ |
| description | ABSTRACT Objective: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. Subjects and methods: Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. Results: We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment–insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). Conclusion: We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement. |
| first_indexed | 2024-04-11T17:19:02Z |
| format | Article |
| id | doaj.art-60273c6431b34c248b22db8c77a5e027 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-11T17:19:02Z |
| publishDate | 2020-08-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-60273c6431b34c248b22db8c77a5e0272022-12-22T04:12:32ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922020-08-0164675876310.20945/2359-3997000000287Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndromeRodrigo de Azeredo Siqueirahttps://orcid.org/0000-0002-2967-678XAluana Santana Carloshttps://orcid.org/0000-0001-5032-5784Joana Costa d'Avilahttps://orcid.org/0000-0002-2045-0813Adalgiza Mafra Morenohttps://orcid.org/0000-0003-3681-7314Estela Luz Alveshttps://orcid.org/0000-0002-2364-1914Maria Lucia Fleiuss de Fariashttps://orcid.org/0000-0003-0466-3250Laura Maria C. Mendonçahttps://orcid.org/0000-0003-2129-3546Marilia Martins Guimarãeshttps://orcid.org/0000-0001-7831-354XABSTRACT Objective: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. Subjects and methods: Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. Results: We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment–insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). Conclusion: We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600758&tlng=enHyperlipidemiahormone replacement therapyTurner's syndromeestrogen replacement therapyinsulin resistance |
| spellingShingle | Rodrigo de Azeredo Siqueira Aluana Santana Carlos Joana Costa d'Avila Adalgiza Mafra Moreno Estela Luz Alves Maria Lucia Fleiuss de Farias Laura Maria C. Mendonça Marilia Martins Guimarães Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome Archives of Endocrinology and Metabolism Hyperlipidemia hormone replacement therapy Turner's syndrome estrogen replacement therapy insulin resistance |
| title | Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome |
| title_full | Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome |
| title_fullStr | Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome |
| title_full_unstemmed | Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome |
| title_short | Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome |
| title_sort | body composition but not insulin resistance influences postprandial lipemia in patients with turner s syndrome |
| topic | Hyperlipidemia hormone replacement therapy Turner's syndrome estrogen replacement therapy insulin resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600758&tlng=en |
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