Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients
Lipid metabolism in cancer refers to the alterations in how cancer cells process and utilize lipids, a type of fat molecule. It was investigated how lipid metabolism relates to osteosarcoma. Genes relevant to lipid metabolism were gathered to create lipid metabolism-associated clusters and locate th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023107079 |
| _version_ | 1797337027730997248 |
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| author | Yanbin Shi Song Wu Xiaolin Zhang Yangbo Cao Lina Zhang |
| author_facet | Yanbin Shi Song Wu Xiaolin Zhang Yangbo Cao Lina Zhang |
| author_sort | Yanbin Shi |
| collection | DOAJ |
| description | Lipid metabolism in cancer refers to the alterations in how cancer cells process and utilize lipids, a type of fat molecule. It was investigated how lipid metabolism relates to osteosarcoma. Genes relevant to lipid metabolism were gathered to create lipid metabolism-associated clusters and locate the dangerous marker. We investigated FAAH's prognostic significance, route annotation, immunotherapy response, and medication prediction. Besides, FAAH is proven to be a potent, dangerous marker that may promote growth and migration and inhibit the apoptosis of osteosarcoma. FAAH exhibits higher expression levels in tumor tissues as compared to normal tissues. In conclusion, FAAH is identified in this work as a potentially dangerous gene and immunotherapy determinant. This study requires more investigation to determine how FAAH influences the immune response in osteosarcoma. |
| first_indexed | 2024-03-08T09:03:26Z |
| format | Article |
| id | doaj.art-6027893904b346ca89a6be2a91a93363 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:03:26Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6027893904b346ca89a6be2a91a933632024-02-01T06:32:08ZengElsevierHeliyon2405-84402024-01-01101e23499Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patientsYanbin Shi0Song Wu1Xiaolin Zhang2Yangbo Cao3Lina Zhang4Department of Orthopaedics, The 3rd Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, The 3rd Xiangya Hospital, Central South University, Changsha, ChinaThe 3rd Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, The 3rd Xiangya Hospital, Central South University, Changsha, ChinaHunan Provincial People's Hospital, Changsha, China; Corresponding author.Lipid metabolism in cancer refers to the alterations in how cancer cells process and utilize lipids, a type of fat molecule. It was investigated how lipid metabolism relates to osteosarcoma. Genes relevant to lipid metabolism were gathered to create lipid metabolism-associated clusters and locate the dangerous marker. We investigated FAAH's prognostic significance, route annotation, immunotherapy response, and medication prediction. Besides, FAAH is proven to be a potent, dangerous marker that may promote growth and migration and inhibit the apoptosis of osteosarcoma. FAAH exhibits higher expression levels in tumor tissues as compared to normal tissues. In conclusion, FAAH is identified in this work as a potentially dangerous gene and immunotherapy determinant. This study requires more investigation to determine how FAAH influences the immune response in osteosarcoma.http://www.sciencedirect.com/science/article/pii/S2405844023107079 |
| spellingShingle | Yanbin Shi Song Wu Xiaolin Zhang Yangbo Cao Lina Zhang Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients Heliyon |
| title | Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients |
| title_full | Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients |
| title_fullStr | Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients |
| title_full_unstemmed | Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients |
| title_short | Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients |
| title_sort | lipid metabolism derived faah is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023107079 |
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