Characterization and inhibition of inflammasome responses in severe and non-severe asthma

Characterization and inhibition of inflammasome responses in severe and non-severe asthma

Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all inflammatory types of severe asthma, and whether inflamm...

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Bibliographic Details
Main Authors: Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Respiratory Research
Subjects:
Asthma
Severe asthma
NLRP3 inflammasome
IL-1β
Inflammasome inhibition
Online Access:https://doi.org/10.1186/s12931-023-02603-2

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