A comparative analysis of parechovirus protein structures with other picornaviruses
Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2021-07-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.210008 |
| _version_ | 1811299668415479808 |
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| author | Aušra Domanska Sergey Guryanov Sarah J. Butcher |
| author_facet | Aušra Domanska Sergey Guryanov Sarah J. Butcher |
| author_sort | Aušra Domanska |
| collection | DOAJ |
| description | Parechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species and can cause infections ranging from mild gastrointestinal or respiratory illness to severe neonatal sepsis. There are no approved antivirals available to treat parechovirus (nor any other picornavirus) infections. In this parechovirus review, we focus on the cleaved protein products resulting from the polyprotein processing after translation comparing and contrasting their known or predicted structures and functions to those of other picornaviruses. The review also includes our original analysis from sequence and structure prediction. This review highlights significant structural differences between parechoviral and other picornaviral proteins, suggesting that parechovirus drug development should specifically be directed to parechoviral targets. |
| first_indexed | 2024-04-13T06:39:22Z |
| format | Article |
| id | doaj.art-6029cfda829a413a8841a76744f2ac66 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-04-13T06:39:22Z |
| publishDate | 2021-07-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-6029cfda829a413a8841a76744f2ac662022-12-22T02:57:47ZengThe Royal SocietyOpen Biology2046-24412021-07-0111710.1098/rsob.210008A comparative analysis of parechovirus protein structures with other picornavirusesAušra Domanska0Sergey Guryanov1Sarah J. Butcher2Faculty of Biological and Environmental Sciences, Molecular and Integrative Bioscience Research Programme, and Helsinki Institute of Life Sciences–Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, FinlandFaculty of Biological and Environmental Sciences, Molecular and Integrative Bioscience Research Programme, and Helsinki Institute of Life Sciences–Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, FinlandFaculty of Biological and Environmental Sciences, Molecular and Integrative Bioscience Research Programme, and Helsinki Institute of Life Sciences–Institute of Biotechnology, University of Helsinki, FI-00014 Helsinki, FinlandParechoviruses belong to the genus Parechovirus within the family Picornaviridae and are non-enveloped icosahedral viruses with a single-stranded RNA genome. Parechoviruses include human and animal pathogens classified into six species. Those that infect humans belong to the Parechovirus A species and can cause infections ranging from mild gastrointestinal or respiratory illness to severe neonatal sepsis. There are no approved antivirals available to treat parechovirus (nor any other picornavirus) infections. In this parechovirus review, we focus on the cleaved protein products resulting from the polyprotein processing after translation comparing and contrasting their known or predicted structures and functions to those of other picornaviruses. The review also includes our original analysis from sequence and structure prediction. This review highlights significant structural differences between parechoviral and other picornaviral proteins, suggesting that parechovirus drug development should specifically be directed to parechoviral targets.https://royalsocietypublishing.org/doi/10.1098/rsob.210008picornavirusparechovirusstructureRNA stem-loopfunction |
| spellingShingle | Aušra Domanska Sergey Guryanov Sarah J. Butcher A comparative analysis of parechovirus protein structures with other picornaviruses Open Biology picornavirus parechovirus structure RNA stem-loop function |
| title | A comparative analysis of parechovirus protein structures with other picornaviruses |
| title_full | A comparative analysis of parechovirus protein structures with other picornaviruses |
| title_fullStr | A comparative analysis of parechovirus protein structures with other picornaviruses |
| title_full_unstemmed | A comparative analysis of parechovirus protein structures with other picornaviruses |
| title_short | A comparative analysis of parechovirus protein structures with other picornaviruses |
| title_sort | comparative analysis of parechovirus protein structures with other picornaviruses |
| topic | picornavirus parechovirus structure RNA stem-loop function |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.210008 |
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