Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study
<b>Background</b>: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/18/5939 |
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| author | Justine Benoit-Piau Karine Tremblay Alain Piché Frédéric Dallaire Mathieu Bélanger Marc-André d’Entremont Jean-Charles Pasquier Martin Fortin Catherine Bourque Fanny Lapointe Jean-François Betala-Belinga Geneviève Petit Guillaume Jourdan Renata Bahous Camilo Maya Amira Benzina Muhammad Faiyaz Hossain Marie-Audrey Peel Olivier Houle Marie-Sandrine Auger Antoine Rioux Paul Farand |
| author_facet | Justine Benoit-Piau Karine Tremblay Alain Piché Frédéric Dallaire Mathieu Bélanger Marc-André d’Entremont Jean-Charles Pasquier Martin Fortin Catherine Bourque Fanny Lapointe Jean-François Betala-Belinga Geneviève Petit Guillaume Jourdan Renata Bahous Camilo Maya Amira Benzina Muhammad Faiyaz Hossain Marie-Audrey Peel Olivier Houle Marie-Sandrine Auger Antoine Rioux Paul Farand |
| author_sort | Justine Benoit-Piau |
| collection | DOAJ |
| description | <b>Background</b>: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. <b>Objective</b>: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. <b>Methods</b>: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. <b>Results</b>: A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). <b>Conclusions</b>: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue. |
| first_indexed | 2024-03-10T22:37:10Z |
| format | Article |
| id | doaj.art-602a48eecc454990a44557c66e93b758 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T22:37:10Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-602a48eecc454990a44557c66e93b7582023-11-19T11:19:31ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011218593910.3390/jcm12185939Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based StudyJustine Benoit-Piau0Karine Tremblay1Alain Piché2Frédéric Dallaire3Mathieu Bélanger4Marc-André d’Entremont5Jean-Charles Pasquier6Martin Fortin7Catherine Bourque8Fanny Lapointe9Jean-François Betala-Belinga10Geneviève Petit11Guillaume Jourdan12Renata Bahous13Camilo Maya14Amira Benzina15Muhammad Faiyaz Hossain16Marie-Audrey Peel17Olivier Houle18Marie-Sandrine Auger19Antoine Rioux20Paul Farand21Research Center of the Centre Hospitalier Universitaire de Sherbrooke (CHUS), University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaPharmacology and Physiology Department, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDepartment of Microbiology and Infectiology, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDepartment of Pediatrics, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDepartment of Family and Emergency Medicine, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDivision of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDepartment of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDepartment of Family and Emergency Medicine, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDivision of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaPharmacology and Physiology Department, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDirection of Saguenay-Lac-Saint-Jean Public Health Department, Saguenay, QC J1H 5N4, CanadaDepartment of Community Health Sciences, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDepartment of Microbiology and Infectiology, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, CanadaDivision of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada<b>Background</b>: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. <b>Objective</b>: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. <b>Methods</b>: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. <b>Results</b>: A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). <b>Conclusions</b>: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue.https://www.mdpi.com/2077-0383/12/18/5939COVID-19post-acute COVID-19 syndromehealth-related quality of liferisk factors |
| spellingShingle | Justine Benoit-Piau Karine Tremblay Alain Piché Frédéric Dallaire Mathieu Bélanger Marc-André d’Entremont Jean-Charles Pasquier Martin Fortin Catherine Bourque Fanny Lapointe Jean-François Betala-Belinga Geneviève Petit Guillaume Jourdan Renata Bahous Camilo Maya Amira Benzina Muhammad Faiyaz Hossain Marie-Audrey Peel Olivier Houle Marie-Sandrine Auger Antoine Rioux Paul Farand Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study Journal of Clinical Medicine COVID-19 post-acute COVID-19 syndrome health-related quality of life risk factors |
| title | Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study |
| title_full | Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study |
| title_fullStr | Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study |
| title_full_unstemmed | Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study |
| title_short | Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study |
| title_sort | long term consequences of covid 19 in predominantly immunonaive patients a canadian prospective population based study |
| topic | COVID-19 post-acute COVID-19 syndrome health-related quality of life risk factors |
| url | https://www.mdpi.com/2077-0383/12/18/5939 |
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