Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients
Background: Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There is controversy over the optimal hemoglobin (Hb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) pat...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2015-03-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913214001533 |
| _version_ | 1819063338257088512 |
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| author | Mi Yeon Jung Soon Young Hwang Yu Ah Hong Su Young Oh Jae Hee Seo Young Mo Lee Sang Won Park Jung Sun Kim Joon Kwang Wang Jeong Yup Kim Ji Eun Lee Gang Jee Ko Heui Jung Pyo Young Joo Kwon |
| author_facet | Mi Yeon Jung Soon Young Hwang Yu Ah Hong Su Young Oh Jae Hee Seo Young Mo Lee Sang Won Park Jung Sun Kim Joon Kwang Wang Jeong Yup Kim Ji Eun Lee Gang Jee Ko Heui Jung Pyo Young Joo Kwon |
| author_sort | Mi Yeon Jung |
| collection | DOAJ |
| description | Background: Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There is controversy over the optimal hemoglobin (Hb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) patients in Korea.
Methods: This study was a multicenter prospective observational study of maintenance HD patients that was performed for 5 years in western Seoul, Korea. Three hundred and sixty-two participants were enrolled. Laboratory values and mortality were accessed every 6 months. Repeated measures of laboratory values in each interval were averaged to obtain one semiannual mean value. The Hb values were divided into six groups: (1) Hb<9 g/dL; (2) 9 g/dL≤Hb<10 g/dL; (3) 10 g/dL≤Hb<11 g/dL; (4) 11 g/dL≤Hb<12 g/dL; (5) 12 g/dL≤Hb<13 g/dL; and (6) Hb≥13 g/dL. We analyzed the odds ratio for all-cause mortality, based on the Hb group, and adjusted for demographics and various laboratory values. Statistics were performed with SAS, version 9.1 software (SAS Institute Inc., Cary, NC, USA).
Results: Mortality odds ratios relative to the reference group (10–11 g/dL) in the fully adjusted model were 3.61 for<9 g/dL; 3.17 for 9–10 g/dL⁎; 4.65 for 11–12 g/dL⁎; 5.50 for 12–13 g/dL⁎; and 2.05 for≥13 g/dL (⁎ indicates P<0.05).
Conclusion: In this study, a Hb level of 10–11 g/dL was associated with the lowest mortality among the groups with Hb level<13 g/dL. Larger interventional trials are warranted to determine the optimal Hb target for Korean HD patients. |
| first_indexed | 2024-12-21T15:13:05Z |
| format | Article |
| id | doaj.art-602cdcf36ac04e5c9ba0d8c4d114e7c9 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-21T15:13:05Z |
| publishDate | 2015-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-602cdcf36ac04e5c9ba0d8c4d114e7c92022-12-21T18:59:13ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322015-03-01341202710.1016/j.krcp.2014.11.003Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patientsMi Yeon Jung0Soon Young Hwang1Yu Ah Hong2Su Young Oh3Jae Hee Seo4Young Mo Lee5Sang Won Park6Jung Sun Kim7Joon Kwang Wang8Jeong Yup Kim9Ji Eun Lee10Gang Jee Ko11Heui Jung Pyo12Young Joo Kwon13Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDepartment of Biostatistics, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaInstitute of Kidney Disease Research, Korea University College of Medicine, Seoul, KoreaInstitute of Kidney Disease Research, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Won Kwang University College of Medicine, Iksan, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaBackground: Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There is controversy over the optimal hemoglobin (Hb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) patients in Korea. Methods: This study was a multicenter prospective observational study of maintenance HD patients that was performed for 5 years in western Seoul, Korea. Three hundred and sixty-two participants were enrolled. Laboratory values and mortality were accessed every 6 months. Repeated measures of laboratory values in each interval were averaged to obtain one semiannual mean value. The Hb values were divided into six groups: (1) Hb<9 g/dL; (2) 9 g/dL≤Hb<10 g/dL; (3) 10 g/dL≤Hb<11 g/dL; (4) 11 g/dL≤Hb<12 g/dL; (5) 12 g/dL≤Hb<13 g/dL; and (6) Hb≥13 g/dL. We analyzed the odds ratio for all-cause mortality, based on the Hb group, and adjusted for demographics and various laboratory values. Statistics were performed with SAS, version 9.1 software (SAS Institute Inc., Cary, NC, USA). Results: Mortality odds ratios relative to the reference group (10–11 g/dL) in the fully adjusted model were 3.61 for<9 g/dL; 3.17 for 9–10 g/dL⁎; 4.65 for 11–12 g/dL⁎; 5.50 for 12–13 g/dL⁎; and 2.05 for≥13 g/dL (⁎ indicates P<0.05). Conclusion: In this study, a Hb level of 10–11 g/dL was associated with the lowest mortality among the groups with Hb level<13 g/dL. Larger interventional trials are warranted to determine the optimal Hb target for Korean HD patients.http://www.sciencedirect.com/science/article/pii/S2211913214001533AnemiaHemodialysisHemoglobinMortality |
| spellingShingle | Mi Yeon Jung Soon Young Hwang Yu Ah Hong Su Young Oh Jae Hee Seo Young Mo Lee Sang Won Park Jung Sun Kim Joon Kwang Wang Jeong Yup Kim Ji Eun Lee Gang Jee Ko Heui Jung Pyo Young Joo Kwon Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients Kidney Research and Clinical Practice Anemia Hemodialysis Hemoglobin Mortality |
| title | Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients |
| title_full | Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients |
| title_fullStr | Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients |
| title_full_unstemmed | Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients |
| title_short | Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients |
| title_sort | optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients |
| topic | Anemia Hemodialysis Hemoglobin Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2211913214001533 |
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