Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine
This study investigated the frequency of adverse reactions to COVID-19 vaccines in Japan and the impact of first-dose adverse reactions on second-dose adverse reactions. Individuals who received an mRNA COVID-19 vaccine at our center in March or April 2021 were included. Data were collected using qu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/8/1232 |
| _version_ | 1827598079990169600 |
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| author | Ken Goda Tsuneaki Kenzaka Shinsuke Yahata Masanobu Okayama Hogara Nishisaki |
| author_facet | Ken Goda Tsuneaki Kenzaka Shinsuke Yahata Masanobu Okayama Hogara Nishisaki |
| author_sort | Ken Goda |
| collection | DOAJ |
| description | This study investigated the frequency of adverse reactions to COVID-19 vaccines in Japan and the impact of first-dose adverse reactions on second-dose adverse reactions. Individuals who received an mRNA COVID-19 vaccine at our center in March or April 2021 were included. Data were collected using questionnaires. The main factors were age (<40, 40–59, and >60 years), sex, underlying disease, and first-dose adverse reaction. The primary outcomes were incidence of local and systemic adverse reactions (ARs) attributable to the vaccine. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Among 671 participants, 90% experienced local or systemic ARs. An AR to the first dose was associated with a significantly increased risk of an AR to the second dose (OR: 49.63, 95% CI: 21.96–112.16). ARs were less common among men than among women (OR: 0.36, 95% CI: 0.17–0.76). Local ARs were less common among those aged 60 years or older (OR: 0.35, 95% CI: 0.18–0.66), whereas systemic ARs were more common among those aged under 40 years. Information on ARs to the first dose is important for healthcare providers and recipients when making vaccination decisions. |
| first_indexed | 2024-03-09T03:43:25Z |
| format | Article |
| id | doaj.art-6037821541064ceebcb830ebc8f2d7c3 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T03:43:25Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6037821541064ceebcb830ebc8f2d7c32023-12-03T14:36:49ZengMDPI AGVaccines2076-393X2022-07-01108123210.3390/vaccines10081232Association between Adverse Reactions to the First and Second Doses of COVID-19 VaccineKen Goda0Tsuneaki Kenzaka1Shinsuke Yahata2Masanobu Okayama3Hogara Nishisaki4Hyogo Prefectural Tamba Medical Center, Department of Internal Medicine, 2002-7 Iso, Hikami-cho, Tamba 669-3495, JapanHyogo Prefectural Tamba Medical Center, Department of Internal Medicine, 2002-7 Iso, Hikami-cho, Tamba 669-3495, JapanHyogo Prefectural Harima-Himeji General Medical Center, Department of General Internal Medicine, 3-264 Kamiya-cho, Himeji 670-8560, JapanDivision of Community Medicine and Medical Education, Kobe University Graduate School of Medicine, 2-1-5 Arata-cho, Hyogo-ku, Kobe 652-0032, JapanHyogo Prefectural Tamba Medical Center, Department of Internal Medicine, 2002-7 Iso, Hikami-cho, Tamba 669-3495, JapanThis study investigated the frequency of adverse reactions to COVID-19 vaccines in Japan and the impact of first-dose adverse reactions on second-dose adverse reactions. Individuals who received an mRNA COVID-19 vaccine at our center in March or April 2021 were included. Data were collected using questionnaires. The main factors were age (<40, 40–59, and >60 years), sex, underlying disease, and first-dose adverse reaction. The primary outcomes were incidence of local and systemic adverse reactions (ARs) attributable to the vaccine. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Among 671 participants, 90% experienced local or systemic ARs. An AR to the first dose was associated with a significantly increased risk of an AR to the second dose (OR: 49.63, 95% CI: 21.96–112.16). ARs were less common among men than among women (OR: 0.36, 95% CI: 0.17–0.76). Local ARs were less common among those aged 60 years or older (OR: 0.35, 95% CI: 0.18–0.66), whereas systemic ARs were more common among those aged under 40 years. Information on ARs to the first dose is important for healthcare providers and recipients when making vaccination decisions.https://www.mdpi.com/2076-393X/10/8/1232COVID-19 vaccineadverse reactionsfirst dosesecond dose |
| spellingShingle | Ken Goda Tsuneaki Kenzaka Shinsuke Yahata Masanobu Okayama Hogara Nishisaki Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine Vaccines COVID-19 vaccine adverse reactions first dose second dose |
| title | Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine |
| title_full | Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine |
| title_fullStr | Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine |
| title_full_unstemmed | Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine |
| title_short | Association between Adverse Reactions to the First and Second Doses of COVID-19 Vaccine |
| title_sort | association between adverse reactions to the first and second doses of covid 19 vaccine |
| topic | COVID-19 vaccine adverse reactions first dose second dose |
| url | https://www.mdpi.com/2076-393X/10/8/1232 |
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