Parameter Screening and Optimization for a Polycaprolactone-Based GTR/GBR Membrane Using Taguchi Design
Our objective was to determine and optimize the significant parameters affecting mechanical properties and mean fiber diameter (MFD) of a novel GTR/GBR membrane composed of polycaprolactone (PCL) and chicken eggshell membrane (ESM). For this, we prepared electrospun membrane specimens (<i>n<...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/15/8149 |
| Summary: | Our objective was to determine and optimize the significant parameters affecting mechanical properties and mean fiber diameter (MFD) of a novel GTR/GBR membrane composed of polycaprolactone (PCL) and chicken eggshell membrane (ESM). For this, we prepared electrospun membrane specimens (<i>n</i> = 16) with varying concentrations of PCL, ESM, nano-hydroxyapatite (HAp), and altered electrospinning parameters as generated by DOE++ software. After the determination of MFD and mechanical properties for all specimens, Taguchi orthogonal array L8 design was used to screen significant factors affecting the MFD and mechanical properties. PCL wt%, ESM wt%, HAp wt%, applied voltage (AV), flow rate (FR), and spinneret-collector distance (SCD) were the independent variables investigated. The response variables analyzed were MFD, tensile strength (TS), and elastic modulus. ANOVA outlined ESM wt%, HAp wt%, AV, FR, SCD, and an interactive effect between PCL wt% and AV to be the significant factors affecting modulus values of an electrospun PCL/ESM membrane (<i>p</i> < 0.05). Furthermore, concentrations of PCL and ESM were the significant factors affecting MFD (<i>p</i> < 0.05) and there were no significant factors affecting the TS values. Optimization using DOE++ software predicted that the maximal TS of 3.125 MPa, modulus of 278.168 MPa, and MFD of 882.75 nm could be achieved. |
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| ISSN: | 1661-6596 1422-0067 |