Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug
In the present work, a chemically modified electrode has been fabricated utilizing Bi2O3/ZnO nanocomposite. The nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD, FESEM, EDAX, HRTEM and XPS techniques. The resul...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177919309864 |
| _version_ | 1819064676020912128 |
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| author | Sana Ansari M. Shahnawaze Ansari Soami P. Satsangee Rajeev Jain |
| author_facet | Sana Ansari M. Shahnawaze Ansari Soami P. Satsangee Rajeev Jain |
| author_sort | Sana Ansari |
| collection | DOAJ |
| description | In the present work, a chemically modified electrode has been fabricated utilizing Bi2O3/ZnO nanocomposite. The nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD, FESEM, EDAX, HRTEM and XPS techniques. The results clearly indicated co-existence of Bi2O3 and ZnO in the nanocomposite with chemical interaction between them. Bi2O3/ZnO nanocomposite based glassy carbon electrode (GCE) was utilized for sensitive voltammetric detection of an anti-biotic drug (balofloxacin). The modification amplified the electroactive surface area of the sensor, thus providing more sites for oxidation of analyte. Cyclic and square wave voltammograms revealed that Bi2O3/ZnO modified electrode provides excellent electrocatalytic action towards balofloxacin oxidation. The current exhibited a wide linear response in concentration range of 150–1000 nM and detection limit of 40.5 nM was attained. The modified electrode offered advantages in terms of simplicity of preparation, fair stability (RSD 1.45%), appreciable reproducibility (RSD 2.03%) and selectivity. The proposed sensor was applied for determining balofloxacin in commercial pharmaceutical formulations and blood serum samples with the mean recoveries of 99.09% and 99.5%, respectively. |
| first_indexed | 2024-12-21T15:34:21Z |
| format | Article |
| id | doaj.art-603bfb0f15f346dc8383c1c9a142582a |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-12-21T15:34:21Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-603bfb0f15f346dc8383c1c9a142582a2022-12-21T18:58:41ZengElsevierJournal of Pharmaceutical Analysis2095-17792021-02-011115767Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drugSana Ansari0M. Shahnawaze Ansari1Soami P. Satsangee2Rajeev Jain3Department of Chemistry, Dayalbagh Educational Institute, Dayalbagh, Agra, 282005, IndiaCenter of Nanotechnology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia; School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia; Corresponding author. Center of Nanotechnology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.Department of Chemistry, Dayalbagh Educational Institute, Dayalbagh, Agra, 282005, India; Corresponding author.School of Studies in Chemistry, Jiwaji University, Gwalior, 474011, IndiaIn the present work, a chemically modified electrode has been fabricated utilizing Bi2O3/ZnO nanocomposite. The nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD, FESEM, EDAX, HRTEM and XPS techniques. The results clearly indicated co-existence of Bi2O3 and ZnO in the nanocomposite with chemical interaction between them. Bi2O3/ZnO nanocomposite based glassy carbon electrode (GCE) was utilized for sensitive voltammetric detection of an anti-biotic drug (balofloxacin). The modification amplified the electroactive surface area of the sensor, thus providing more sites for oxidation of analyte. Cyclic and square wave voltammograms revealed that Bi2O3/ZnO modified electrode provides excellent electrocatalytic action towards balofloxacin oxidation. The current exhibited a wide linear response in concentration range of 150–1000 nM and detection limit of 40.5 nM was attained. The modified electrode offered advantages in terms of simplicity of preparation, fair stability (RSD 1.45%), appreciable reproducibility (RSD 2.03%) and selectivity. The proposed sensor was applied for determining balofloxacin in commercial pharmaceutical formulations and blood serum samples with the mean recoveries of 99.09% and 99.5%, respectively.http://www.sciencedirect.com/science/article/pii/S2095177919309864ZnO nanoparticlesChemically modified electrodeVoltammetryDrug analysis |
| spellingShingle | Sana Ansari M. Shahnawaze Ansari Soami P. Satsangee Rajeev Jain Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug Journal of Pharmaceutical Analysis ZnO nanoparticles Chemically modified electrode Voltammetry Drug analysis |
| title | Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug |
| title_full | Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug |
| title_fullStr | Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug |
| title_full_unstemmed | Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug |
| title_short | Bi2O3/ZnO nanocomposite: Synthesis, characterizations and its application in electrochemical detection of balofloxacin as an anti-biotic drug |
| title_sort | bi2o3 zno nanocomposite synthesis characterizations and its application in electrochemical detection of balofloxacin as an anti biotic drug |
| topic | ZnO nanoparticles Chemically modified electrode Voltammetry Drug analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2095177919309864 |
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