PI3K/AKT信号通路介导脂联素对脑缺血再灌注大鼠的保护作用 The Protective Effect of Adiponectin on Rats with Cerebral Ischemia-reperfusion through PI3K/PKB Signaling Pathway
目的 探讨磷脂酰肌醇3激酶/蛋白激酶B（phosphatidylinositol-3-kinase/protein kinase B，PI3K/PKB）信号通路介导脂联素对脑缺血再灌注大鼠的保护作用。 方法 随机将SD大鼠分为假手术组、模型组、脂联素治疗组和PI3K/PKB抑制剂LY294002组（抑制剂组），每组15只。通过线栓法构建大脑中动脉缺血模型，缺血1.5 h后再灌注。脂联素治疗组在再灌注2 h后，给予大鼠尾静脉注射脂联素（180 μg/100 g）；抑制剂组在再灌注2 h后给予大鼠尾静脉注射脂联素（180 μg/100 g）+LY294004（0.03 mg/100 g）；假手术组...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Chinese Journal of Stroke
2022-08-01
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| Series: | Zhongguo cuzhong zazhi |
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| Online Access: | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=3618 |