Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities
Pinki Rawat, Saurabh Manaswita Verma Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India Abstract: A series of chroman derivatives was designed, prepared, and examined for their anti-breast cancer and antiepileptic activities. All sy...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-09-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/design-and-synthesis-of-chroman-derivatives-with-dual-anti-breast-canc-peer-reviewed-article-DDDT |
| _version_ | 1811338467610722304 |
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| author | Rawat P Verma SM |
| author_facet | Rawat P Verma SM |
| author_sort | Rawat P |
| collection | DOAJ |
| description | Pinki Rawat, Saurabh Manaswita Verma Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India Abstract: A series of chroman derivatives was designed, prepared, and examined for their anti-breast cancer and antiepileptic activities. All synthesized compounds yielded results that were in good agreement with spectral data. The bioassay showed that some of the resultant compounds exerted remarkable inhibitory effects on growth of human breast cancer cell line MCF-7. In particular, compound 6i (the concentration required for 50% inhibition of cell growth [GI50] =34.7 µM) exerted promising anticancer activity toward MCF-7 cell line. Additionally, compounds 6b, 6c, 6d, 6e, 6g, 6i, and 6l showed advanced antiepileptic activity than reference drugs. None of the compounds showed neurotoxicity, as determined by the rotarod test. The obtained results proved that these distinctive compounds could be relevant as models for future discovery and research, as well as for the production of more number of active derivatives. Keywords: anti-breast cancer, antiepileptic, chroman, isatin, Schiff base |
| first_indexed | 2024-04-13T18:11:10Z |
| format | Article |
| id | doaj.art-60413fe4baea45c7bdee9807d506ebb5 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-04-13T18:11:10Z |
| publishDate | 2016-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-60413fe4baea45c7bdee9807d506ebb52022-12-22T02:35:53ZengDove Medical PressDrug Design, Development and Therapy1177-88812016-09-01Volume 102779278828725Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activitiesRawat PVerma SMPinki Rawat, Saurabh Manaswita Verma Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India Abstract: A series of chroman derivatives was designed, prepared, and examined for their anti-breast cancer and antiepileptic activities. All synthesized compounds yielded results that were in good agreement with spectral data. The bioassay showed that some of the resultant compounds exerted remarkable inhibitory effects on growth of human breast cancer cell line MCF-7. In particular, compound 6i (the concentration required for 50% inhibition of cell growth [GI50] =34.7 µM) exerted promising anticancer activity toward MCF-7 cell line. Additionally, compounds 6b, 6c, 6d, 6e, 6g, 6i, and 6l showed advanced antiepileptic activity than reference drugs. None of the compounds showed neurotoxicity, as determined by the rotarod test. The obtained results proved that these distinctive compounds could be relevant as models for future discovery and research, as well as for the production of more number of active derivatives. Keywords: anti-breast cancer, antiepileptic, chroman, isatin, Schiff basehttps://www.dovepress.com/design-and-synthesis-of-chroman-derivatives-with-dual-anti-breast-canc-peer-reviewed-article-DDDTAnti-breast cancerAntiepilepticChromanIsatinSchiff base |
| spellingShingle | Rawat P Verma SM Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities Drug Design, Development and Therapy Anti-breast cancer Antiepileptic Chroman Isatin Schiff base |
| title | Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities |
| title_full | Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities |
| title_fullStr | Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities |
| title_full_unstemmed | Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities |
| title_short | Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities |
| title_sort | design and synthesis of chroman derivatives with dual anti breast cancer and antiepileptic activities |
| topic | Anti-breast cancer Antiepileptic Chroman Isatin Schiff base |
| url | https://www.dovepress.com/design-and-synthesis-of-chroman-derivatives-with-dual-anti-breast-canc-peer-reviewed-article-DDDT |
| work_keys_str_mv | AT rawatp designandsynthesisofchromanderivativeswithdualantibreastcancerandantiepilepticactivities AT vermasm designandsynthesisofchromanderivativeswithdualantibreastcancerandantiepilepticactivities |