The association between naturalistic use of psychedelics and co-occurring substance use disorders
ObjectiveClassic psychedelics (LSD, psilocybin, and peyote/mescaline) have been used to support addiction treatment in a variety of contexts ranging from ceremonial use to clinical trials. The aim of this study was to test the hypothesis that past naturalistic use of classic psychedelics would be as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1066369/full |
| _version_ | 1797956474013483008 |
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| author | Jonina Rabinowitz Shaul Lev-Ran Shaul Lev-Ran Shaul Lev-Ran Raz Gross Raz Gross Raz Gross |
| author_facet | Jonina Rabinowitz Shaul Lev-Ran Shaul Lev-Ran Shaul Lev-Ran Raz Gross Raz Gross Raz Gross |
| author_sort | Jonina Rabinowitz |
| collection | DOAJ |
| description | ObjectiveClassic psychedelics (LSD, psilocybin, and peyote/mescaline) have been used to support addiction treatment in a variety of contexts ranging from ceremonial use to clinical trials. The aim of this study was to test the hypothesis that past naturalistic use of classic psychedelics would be associated with decreased prevalence of substance use disorder, when controlling for known confounders.MethodsThis cross-sectional study used 2017 NSDUH survey data to evaluate the association between past use of the classic psychedelics LSD, psilocybin and peyote/mescaline and past year substance dependence or abuse. We calculated adjusted odds ratios by multivariate logistic regression, controlling for a range of sociodemographic variables, use of non-psychedelic illicit drugs and mental health related variables.ResultsA total of 56,276 participants were included in this study. Past use of LSD and psilocybin were associated with increased odds of substance dependence or abuse compared to those who had never used psychedelics before, and this was more likely for those who had used LSD more recently. However, prior use of peyote or mescaline was associated with lower odds of past year substance dependence or abuse compared to people who had never used psychedelics before (aOR = 0.68, p < 0.001). Past use of classic psychedelics was not associated with nicotine dependence.ConclusionPast use of peyote/mescaline was associated with decreased odds of substance use disorder compared to people who had never used psychedelics before, while past use of LSD or psilocybin was not. It remains unclear whether this difference is due to pharmacological differences between these compounds or simply due to the context in which peyote/mescaline are traditionally taken. Future research should investigate why naturalistic use of different psychedelics is associated with different substance use disorder effects. |
| first_indexed | 2024-04-10T23:50:09Z |
| format | Article |
| id | doaj.art-60426d1052084c9393d06e3e7b3bd268 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-10T23:50:09Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-60426d1052084c9393d06e3e7b3bd2682023-01-10T19:58:34ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011310.3389/fpsyt.2022.10663691066369The association between naturalistic use of psychedelics and co-occurring substance use disordersJonina Rabinowitz0Shaul Lev-Ran1Shaul Lev-Ran2Shaul Lev-Ran3Raz Gross4Raz Gross5Raz Gross6School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, IsraelLev Hasharon Medical Center, Netanya, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, IsraelIsrael Center on Addictions, Netanya, IsraelSchool of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, IsraelDivision of Psychiatry, Sheba Medical Center, Ramat Gan, IsraelObjectiveClassic psychedelics (LSD, psilocybin, and peyote/mescaline) have been used to support addiction treatment in a variety of contexts ranging from ceremonial use to clinical trials. The aim of this study was to test the hypothesis that past naturalistic use of classic psychedelics would be associated with decreased prevalence of substance use disorder, when controlling for known confounders.MethodsThis cross-sectional study used 2017 NSDUH survey data to evaluate the association between past use of the classic psychedelics LSD, psilocybin and peyote/mescaline and past year substance dependence or abuse. We calculated adjusted odds ratios by multivariate logistic regression, controlling for a range of sociodemographic variables, use of non-psychedelic illicit drugs and mental health related variables.ResultsA total of 56,276 participants were included in this study. Past use of LSD and psilocybin were associated with increased odds of substance dependence or abuse compared to those who had never used psychedelics before, and this was more likely for those who had used LSD more recently. However, prior use of peyote or mescaline was associated with lower odds of past year substance dependence or abuse compared to people who had never used psychedelics before (aOR = 0.68, p < 0.001). Past use of classic psychedelics was not associated with nicotine dependence.ConclusionPast use of peyote/mescaline was associated with decreased odds of substance use disorder compared to people who had never used psychedelics before, while past use of LSD or psilocybin was not. It remains unclear whether this difference is due to pharmacological differences between these compounds or simply due to the context in which peyote/mescaline are traditionally taken. Future research should investigate why naturalistic use of different psychedelics is associated with different substance use disorder effects.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1066369/fullpsychedelic agentsmescalineaddictionsubstance use disorderpopulation study |
| spellingShingle | Jonina Rabinowitz Shaul Lev-Ran Shaul Lev-Ran Shaul Lev-Ran Raz Gross Raz Gross Raz Gross The association between naturalistic use of psychedelics and co-occurring substance use disorders Frontiers in Psychiatry psychedelic agents mescaline addiction substance use disorder population study |
| title | The association between naturalistic use of psychedelics and co-occurring substance use disorders |
| title_full | The association between naturalistic use of psychedelics and co-occurring substance use disorders |
| title_fullStr | The association between naturalistic use of psychedelics and co-occurring substance use disorders |
| title_full_unstemmed | The association between naturalistic use of psychedelics and co-occurring substance use disorders |
| title_short | The association between naturalistic use of psychedelics and co-occurring substance use disorders |
| title_sort | association between naturalistic use of psychedelics and co occurring substance use disorders |
| topic | psychedelic agents mescaline addiction substance use disorder population study |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1066369/full |
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