In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice
In recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs in vivo has been limited due to underlying toxicity caused by leakage of heavy metals. Although non-cadmium QDs ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00437/full |
| _version_ | 1798046046248501248 |
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| author | Wenyi Zou Wenyi Zou Li Li Yajing Chen Tingting Chen Zhiwen Yang Jie Wang Dongmeng Liu Guimiao Lin Xiaomei Wang Xiaomei Wang |
| author_facet | Wenyi Zou Wenyi Zou Li Li Yajing Chen Tingting Chen Zhiwen Yang Jie Wang Dongmeng Liu Guimiao Lin Xiaomei Wang Xiaomei Wang |
| author_sort | Wenyi Zou |
| collection | DOAJ |
| description | In recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs in vivo has been limited due to underlying toxicity caused by leakage of heavy metals. Although non-cadmium QDs have been developed to resolve this issue, a comprehensive understanding of the toxicity of these newly developed QDs remains elusive. In this study, we administered PEGylated copper indium sulfide/zinc sulfide (CuInS2/ZnS), which are typical non-cadmium QDs, and analyzed the long-term effects of these nanoparticles in BALB/c mice. Body weight, hematology, blood biochemistry, organ histology, and biodistribution were examined at different time points. We found no significant difference in body weight after injection of CuInS2/ZnS QDs. These CuInS2/ZnS QDs entered and were accumulated in major organs for 90 days post-injection. The majority of biochemical indicators were not significantly different between the QDs-treated group and the control group. In addition, no significant histopathological abnormalities were observed in the treated mice compared with the control mice. CuInS2/ZnS QDs did not lead to observable toxicity in vivo following either the administration of a high or low dose. Our research not only provides direct evidence of the bio-safety of CuInS2/ZnS QDs, but also a feasible method for evaluating nanoparticle toxicity. |
| first_indexed | 2024-04-11T23:31:09Z |
| format | Article |
| id | doaj.art-6043f3dff7514769ab37ba8b047707dd |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T23:31:09Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-6043f3dff7514769ab37ba8b047707dd2022-12-22T03:57:07ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-04-011010.3389/fphar.2019.00437435178In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c MiceWenyi Zou0Wenyi Zou1Li Li2Yajing Chen3Tingting Chen4Zhiwen Yang5Jie Wang6Dongmeng Liu7Guimiao Lin8Xiaomei Wang9Xiaomei Wang10College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaCollege of Life Sciences and Oceanography, Shenzhen University, Shenzhen, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen University, Shenzhen, ChinaIn recent years, quantum dots (QDs) have emerged as a potential contrast agent for bioimaging due to their bright luminescence and excellent photostability. However, the wide use of QDs in vivo has been limited due to underlying toxicity caused by leakage of heavy metals. Although non-cadmium QDs have been developed to resolve this issue, a comprehensive understanding of the toxicity of these newly developed QDs remains elusive. In this study, we administered PEGylated copper indium sulfide/zinc sulfide (CuInS2/ZnS), which are typical non-cadmium QDs, and analyzed the long-term effects of these nanoparticles in BALB/c mice. Body weight, hematology, blood biochemistry, organ histology, and biodistribution were examined at different time points. We found no significant difference in body weight after injection of CuInS2/ZnS QDs. These CuInS2/ZnS QDs entered and were accumulated in major organs for 90 days post-injection. The majority of biochemical indicators were not significantly different between the QDs-treated group and the control group. In addition, no significant histopathological abnormalities were observed in the treated mice compared with the control mice. CuInS2/ZnS QDs did not lead to observable toxicity in vivo following either the administration of a high or low dose. Our research not only provides direct evidence of the bio-safety of CuInS2/ZnS QDs, but also a feasible method for evaluating nanoparticle toxicity.https://www.frontiersin.org/article/10.3389/fphar.2019.00437/fullCuInS2/ZnS quantum dotsnanotoxicologynon-cadmiumtoxicityin vivo |
| spellingShingle | Wenyi Zou Wenyi Zou Li Li Yajing Chen Tingting Chen Zhiwen Yang Jie Wang Dongmeng Liu Guimiao Lin Xiaomei Wang Xiaomei Wang In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice Frontiers in Pharmacology CuInS2/ZnS quantum dots nanotoxicology non-cadmium toxicity in vivo |
| title | In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice |
| title_full | In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice |
| title_fullStr | In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice |
| title_full_unstemmed | In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice |
| title_short | In Vivo Toxicity Evaluation of PEGylated CuInS2/ZnS Quantum Dots in BALB/c Mice |
| title_sort | in vivo toxicity evaluation of pegylated cuins2 zns quantum dots in balb c mice |
| topic | CuInS2/ZnS quantum dots nanotoxicology non-cadmium toxicity in vivo |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00437/full |
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