Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy
Objective: To determine lipid derangements in HIV-positive patients receiving anti-retroviral therapy (ART). Study Design: Comparative cross-sectional study. Place and Duration of study: Chemical Pathology Department, in cooperation with the Department of Virology at Armed Forces Institute of...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2022-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/5810 |
| _version_ | 1797938533619466240 |
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| author | Qamar Bashir Zujaja Hina Haroon Naveed Asif Muhammad Qaiser Alam Khan Eijaz Ghani Syed Raza Jaffar |
| author_facet | Qamar Bashir Zujaja Hina Haroon Naveed Asif Muhammad Qaiser Alam Khan Eijaz Ghani Syed Raza Jaffar |
| author_sort | Qamar Bashir |
| collection | DOAJ |
| description |
Objective: To determine lipid derangements in HIV-positive patients receiving anti-retroviral therapy (ART).
Study Design: Comparative cross-sectional study.
Place and Duration of study: Chemical Pathology Department, in cooperation with the Department of Virology at Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Mar 2019 to Mar 2020.
Methodology: In this study, two groups were made. In Group-1, lipid profile estimation was done in HIV patients without treatment. In contrast, lipid profile estimation was done after one year of treatment with anti-retroviral drugs in Group-2.
Results: One hundred and two HIV-positive subjects were included in our study. Of these patients, 88(86.27%) were males,and 14(13.73%) were females. Independent sample t-test revealed a statistically significant difference (p-value<0.05) in serum cholesterol, serum triglycerides, serum high-density lipoprotein (HDL-c), low-density lipoproteins (LDL) and very lowdensity lipoproteins (VLDL) between the two groups.
Conclusion: Hyperlipidemia in HIV patients getting anti-retroviral therapy (ART) exposes them to a high risk of coronary artery diseases and myocardial infarction. Hence lipid profile of patients getting ART must be regularly monitored, and hyperlipidemia, if present, should be managed.
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| first_indexed | 2024-04-10T19:02:18Z |
| format | Article |
| id | doaj.art-6044800cf7644eb89204c94c0094f360 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-04-10T19:02:18Z |
| publishDate | 2022-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-6044800cf7644eb89204c94c0094f3602023-01-31T08:20:36ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422022-12-0172610.51253/pafmj.v72i6.5810Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral TherapyQamar Bashir0Zujaja Hina Haroon1Naveed Asif2Muhammad Qaiser Alam Khan3Eijaz Ghani4Syed Raza Jaffar5Armed Forces Institute of Pathology/ National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/ National University of Medical Sciences (NUMS) Rawalpindi PakistanCombined Military Hospital, Quetta/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital, Lahore/National University of Medical Sciences (NUMS) PakistanArmed Forces Institute of Pathology/ National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/ National University of Medical Sciences (NUMS) Rawalpindi Pakistan Objective: To determine lipid derangements in HIV-positive patients receiving anti-retroviral therapy (ART). Study Design: Comparative cross-sectional study. Place and Duration of study: Chemical Pathology Department, in cooperation with the Department of Virology at Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Mar 2019 to Mar 2020. Methodology: In this study, two groups were made. In Group-1, lipid profile estimation was done in HIV patients without treatment. In contrast, lipid profile estimation was done after one year of treatment with anti-retroviral drugs in Group-2. Results: One hundred and two HIV-positive subjects were included in our study. Of these patients, 88(86.27%) were males,and 14(13.73%) were females. Independent sample t-test revealed a statistically significant difference (p-value<0.05) in serum cholesterol, serum triglycerides, serum high-density lipoprotein (HDL-c), low-density lipoproteins (LDL) and very lowdensity lipoproteins (VLDL) between the two groups. Conclusion: Hyperlipidemia in HIV patients getting anti-retroviral therapy (ART) exposes them to a high risk of coronary artery diseases and myocardial infarction. Hence lipid profile of patients getting ART must be regularly monitored, and hyperlipidemia, if present, should be managed. https://pafmj.org/index.php/PAFMJ/article/view/5810Acquired immunodeficiency syndrome (AIDS)Antiretroviral therapy (ART)CholesterolHuman immunodeficiency virus (HIV)hyperlipidemia |
| spellingShingle | Qamar Bashir Zujaja Hina Haroon Naveed Asif Muhammad Qaiser Alam Khan Eijaz Ghani Syed Raza Jaffar Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy Pakistan Armed Forces Medical Journal Acquired immunodeficiency syndrome (AIDS) Antiretroviral therapy (ART) Cholesterol Human immunodeficiency virus (HIV) hyperlipidemia |
| title | Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy |
| title_full | Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy |
| title_fullStr | Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy |
| title_full_unstemmed | Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy |
| title_short | Determination of Lipid Derangements in Human Immunodeficiency Virus Patients Undergoing Anti-Retroviral Therapy |
| title_sort | determination of lipid derangements in human immunodeficiency virus patients undergoing anti retroviral therapy |
| topic | Acquired immunodeficiency syndrome (AIDS) Antiretroviral therapy (ART) Cholesterol Human immunodeficiency virus (HIV) hyperlipidemia |
| url | https://pafmj.org/index.php/PAFMJ/article/view/5810 |
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