Guanidine Derivatives of Quinazoline-2,4(1<i>H</i>,3<i>H</i>)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents

Guanidine Derivatives of Quinazoline-2,4(1<i>H</i>,3<i>H</i>)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents

Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1<i>H</i>,3<i>H</i>)-diones and quinazoline-4(3<i>H&...

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Bibliographic Details
Main Authors: Alexander Spasov, Alexander Ozerov, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Nadezhda Ovsyankina, Alexey Smirnov, Yulia Velikorodnaya
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Life
Subjects:
NHE-1
cytokine release
macrophage
quinazoline-2,4(1<i>H</i>,3<i>H</i>)-dione
lung injury
LPS
Online Access:https://www.mdpi.com/2075-1729/12/10/1647

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https://www.mdpi.com/2075-1729/12/10/1647

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