Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae)
The crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial and anti-inflammatory activities. The ethyl acetate extract and 3′,4′,5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values of MIC = 62.5 and...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535210002960 |
| _version_ | 1819240425227026432 |
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| author | Farediah Ahmad Emrizal Hasnah M. Sirat Fadzureena Jamaludin Nik Musa’adah Mustapha Rasadah M. Ali Dayar Arbain Hassan Y. Aboul-Enein |
| author_facet | Farediah Ahmad Emrizal Hasnah M. Sirat Fadzureena Jamaludin Nik Musa’adah Mustapha Rasadah M. Ali Dayar Arbain Hassan Y. Aboul-Enein |
| author_sort | Farediah Ahmad |
| collection | DOAJ |
| description | The crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial and anti-inflammatory activities. The ethyl acetate extract and 3′,4′,5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values of MIC = 62.5 and 250 μg/mL, respectively. 5-Hydroxy-7-methoxyflavanone and 4′,5-dihydroxy-3′,7-dimethoxyflavone were active against Pseudomonas aeruginosa, both with MIC value 125 μg/mL. The hexane extract and 4′,5-dihydroxy-3′,7-dimethoxyflavone gave the highest anti-inflammatory activity in in vitro quantitative lipoxygenase inhibition assay with inhibitory activity of (IE) 99.72% and 91.81%, respectively. |
| first_indexed | 2024-12-23T14:07:48Z |
| format | Article |
| id | doaj.art-60469ffe60634909b98e7c614aa7c74a |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-23T14:07:48Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-60469ffe60634909b98e7c614aa7c74a2022-12-21T17:44:07ZengElsevierArabian Journal of Chemistry1878-53522014-12-01761031103310.1016/j.arabjc.2010.12.032Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae)Farediah Ahmad0Emrizal1Hasnah M. Sirat2Fadzureena Jamaludin3Nik Musa’adah Mustapha4Rasadah M. Ali5Dayar Arbain6Hassan Y. Aboul-Enein7Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor Bahru, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor Bahru, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, Johor Bahru, MalaysiaForest Research Institute Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, MalaysiaForest Research Institute Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, MalaysiaForest Research Institute Malaysia (FRIM), Kepong, 52109 Kuala Lumpur, MalaysiaDepartment of Pharmacy, Faculty of Science, Andalas University, Padang, IndonesiaPharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12311, EgyptThe crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial and anti-inflammatory activities. The ethyl acetate extract and 3′,4′,5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values of MIC = 62.5 and 250 μg/mL, respectively. 5-Hydroxy-7-methoxyflavanone and 4′,5-dihydroxy-3′,7-dimethoxyflavone were active against Pseudomonas aeruginosa, both with MIC value 125 μg/mL. The hexane extract and 4′,5-dihydroxy-3′,7-dimethoxyflavone gave the highest anti-inflammatory activity in in vitro quantitative lipoxygenase inhibition assay with inhibitory activity of (IE) 99.72% and 91.81%, respectively.http://www.sciencedirect.com/science/article/pii/S1878535210002960Piper porphyrophyllumExtractsFlavonoidsAntibacterialAnti-inflammatory |
| spellingShingle | Farediah Ahmad Emrizal Hasnah M. Sirat Fadzureena Jamaludin Nik Musa’adah Mustapha Rasadah M. Ali Dayar Arbain Hassan Y. Aboul-Enein Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) Arabian Journal of Chemistry Piper porphyrophyllum Extracts Flavonoids Antibacterial Anti-inflammatory |
| title | Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) |
| title_full | Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) |
| title_fullStr | Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) |
| title_full_unstemmed | Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) |
| title_short | Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae) |
| title_sort | antimicrobial and anti inflammatory activities of piper porphyrophyllum fam piperaceae |
| topic | Piper porphyrophyllum Extracts Flavonoids Antibacterial Anti-inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S1878535210002960 |
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