Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study
Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk, sedentarism, depression, anxiety and impaired quality of life. The long-term effectiveness of positive airway pressure (PAP) is insufficiently studied and limited by poor patient compliance. The aim of this pilot prospec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/8/1447 |
| _version_ | 1797605786531135488 |
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| author | Ioana Madalina Zota Mihai Roca Maria Magdalena Leon Corina Dima Cozma Larisa Anghel Cristian Statescu Radu Sascau Monica Hancianu Cornelia Mircea Manuela Ciocoiu Carmen Marinela Cumpat Florin Mitu |
| author_facet | Ioana Madalina Zota Mihai Roca Maria Magdalena Leon Corina Dima Cozma Larisa Anghel Cristian Statescu Radu Sascau Monica Hancianu Cornelia Mircea Manuela Ciocoiu Carmen Marinela Cumpat Florin Mitu |
| author_sort | Ioana Madalina Zota |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk, sedentarism, depression, anxiety and impaired quality of life. The long-term effectiveness of positive airway pressure (PAP) is insufficiently studied and limited by poor patient compliance. The aim of this pilot prospective cohort study was to evaluate long-term adherence in overweight patients with moderate–severe OSA and hypertension and to analyze changes in weight, sleepiness and quality of life. We performed a prospective study that included overweight patients with moderate–severe OSA and hypertension who had not undergone previous PAP therapy. All subjects received a standard physical examination, education regarding lifestyle changes and free PAP therapy for 2 months. After five years, the patients were invited to participate in a telephone-based interview regarding PAP compliance and completed standard questionnaires assessing adherence to medication, physical activity, diet, anxiety and quality of life (QoL). Only 39.58% of the patients were adherent to PAP 5 years (58.42 ± 3.70 months) after being diagnosed with moderate–severe OSA. Long-term PAP use results in sustained weight loss; improved blood pressure control, sleepiness and QOL; and lower anxiety and depression scores. PAP compliance was not associated with a higher level of daily physical activity or a healthier diet. |
| first_indexed | 2024-03-11T05:05:58Z |
| format | Article |
| id | doaj.art-604755767ce246e0808557f831ba6ca7 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T05:05:58Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-604755767ce246e0808557f831ba6ca72023-11-17T18:55:13ZengMDPI AGDiagnostics2075-44182023-04-01138144710.3390/diagnostics13081447Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort StudyIoana Madalina Zota0Mihai Roca1Maria Magdalena Leon2Corina Dima Cozma3Larisa Anghel4Cristian Statescu5Radu Sascau6Monica Hancianu7Cornelia Mircea8Manuela Ciocoiu9Carmen Marinela Cumpat10Florin Mitu11Department of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Pharmacognosy, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Pharmaceutical Sciences (II), Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, RomaniaDepartment of Morpho-Functional Sciences (Pathophysiology), Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (III), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaDepartment of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, RomaniaObstructive sleep apnea (OSA) is associated with increased cardiovascular risk, sedentarism, depression, anxiety and impaired quality of life. The long-term effectiveness of positive airway pressure (PAP) is insufficiently studied and limited by poor patient compliance. The aim of this pilot prospective cohort study was to evaluate long-term adherence in overweight patients with moderate–severe OSA and hypertension and to analyze changes in weight, sleepiness and quality of life. We performed a prospective study that included overweight patients with moderate–severe OSA and hypertension who had not undergone previous PAP therapy. All subjects received a standard physical examination, education regarding lifestyle changes and free PAP therapy for 2 months. After five years, the patients were invited to participate in a telephone-based interview regarding PAP compliance and completed standard questionnaires assessing adherence to medication, physical activity, diet, anxiety and quality of life (QoL). Only 39.58% of the patients were adherent to PAP 5 years (58.42 ± 3.70 months) after being diagnosed with moderate–severe OSA. Long-term PAP use results in sustained weight loss; improved blood pressure control, sleepiness and QOL; and lower anxiety and depression scores. PAP compliance was not associated with a higher level of daily physical activity or a healthier diet.https://www.mdpi.com/2075-4418/13/8/1447obstructive sleep apnea (OSA)positive airway pressure (PAP)adherencequality of lifeanxietyIPAQ-L |
| spellingShingle | Ioana Madalina Zota Mihai Roca Maria Magdalena Leon Corina Dima Cozma Larisa Anghel Cristian Statescu Radu Sascau Monica Hancianu Cornelia Mircea Manuela Ciocoiu Carmen Marinela Cumpat Florin Mitu Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study Diagnostics obstructive sleep apnea (OSA) positive airway pressure (PAP) adherence quality of life anxiety IPAQ-L |
| title | Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study |
| title_full | Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study |
| title_fullStr | Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study |
| title_full_unstemmed | Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study |
| title_short | Long-Term Adherence in Overweight Patients with Obstructive Sleep Apnea and Hypertension—A Pilot Prospective Cohort Study |
| title_sort | long term adherence in overweight patients with obstructive sleep apnea and hypertension a pilot prospective cohort study |
| topic | obstructive sleep apnea (OSA) positive airway pressure (PAP) adherence quality of life anxiety IPAQ-L |
| url | https://www.mdpi.com/2075-4418/13/8/1447 |
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