Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals
Background This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals. Methods The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) witho...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2020.1806292 |
| _version_ | 1797681296134111232 |
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| author | Nobuyuki Miyai Maki Shiozaki Kazufumi Terada Tatsuya Takeshita Miyoko Utsumi Kazuhisa Miyashita Mikio Arita |
| author_facet | Nobuyuki Miyai Maki Shiozaki Kazufumi Terada Tatsuya Takeshita Miyoko Utsumi Kazuhisa Miyashita Mikio Arita |
| author_sort | Nobuyuki Miyai |
| collection | DOAJ |
| description | Background This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals. Methods The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) without a history of cardiovascular disease or stroke. A graded exercise test was conducted using a bicycle ergometer, and the mean arterial pressure (MAP) during submaximal exercise was evaluated. The brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. The second peak of radial systolic BP (SBP2) was used as an estimate of central BP. The albumin-to-creatinine ratio (ACR) values were determined as the mean of two nonconsecutive spot urine specimens. Results Compared with individuals with a normal response (MAP z-score < +1.0, n = 60), those with an exaggerated BP response to exercise (MAP z-score ≥ +1.0, n = 32) exhibited significantly higher baPWV (1412 ± 158 vs. 1250 ± 140 cm/s), radial SBP2 (122 ± 11 vs. 106 ± 13 mmHg), and greater log-ACR (0.93 ± 0.30 vs. 0.59 ± 0.23 mg/gCre). Multiple regression analysis revealed that an exaggerated BP response to exercise was significantly associated with baPWV (β = 0.198, P= .043), radial SBP2 (β = 0.156, P = .049), and log-ACR (β = 0.276, P = .006) independent of potential confounding factors. Conclusions These results suggest that subclinical vascular impairment is associated with an exaggerated increase in BP during exercise even in the absence of clinical hypertension. |
| first_indexed | 2024-03-11T23:42:54Z |
| format | Article |
| id | doaj.art-60495fad793141f0990cfd8640deb183 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:42:54Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-60495fad793141f0990cfd8640deb1832023-09-19T15:19:29ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062021-01-01431566210.1080/10641963.2020.18062921806292Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individualsNobuyuki Miyai0Maki Shiozaki1Kazufumi Terada2Tatsuya Takeshita3Miyoko Utsumi4Kazuhisa Miyashita5Mikio Arita6Wakayama Medical UniversitySchool of Medicine, Wakayama Medical UniversityTenri UniversitySchool of Medicine, Wakayama Medical UniversityWakayama Medical UniversitySchool of Medicine, Wakayama Medical UniversityWakayama Medical UniversityBackground This study was designed to evaluate the possible association between an exaggerated blood pressure (BP) response to exercise and subclinical vascular impairment in normotensive individuals. Methods The study participants consisted of 92 untreated normotensive men (aged 42 ± 9 years) without a history of cardiovascular disease or stroke. A graded exercise test was conducted using a bicycle ergometer, and the mean arterial pressure (MAP) during submaximal exercise was evaluated. The brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. The second peak of radial systolic BP (SBP2) was used as an estimate of central BP. The albumin-to-creatinine ratio (ACR) values were determined as the mean of two nonconsecutive spot urine specimens. Results Compared with individuals with a normal response (MAP z-score < +1.0, n = 60), those with an exaggerated BP response to exercise (MAP z-score ≥ +1.0, n = 32) exhibited significantly higher baPWV (1412 ± 158 vs. 1250 ± 140 cm/s), radial SBP2 (122 ± 11 vs. 106 ± 13 mmHg), and greater log-ACR (0.93 ± 0.30 vs. 0.59 ± 0.23 mg/gCre). Multiple regression analysis revealed that an exaggerated BP response to exercise was significantly associated with baPWV (β = 0.198, P= .043), radial SBP2 (β = 0.156, P = .049), and log-ACR (β = 0.276, P = .006) independent of potential confounding factors. Conclusions These results suggest that subclinical vascular impairment is associated with an exaggerated increase in BP during exercise even in the absence of clinical hypertension.http://dx.doi.org/10.1080/10641963.2020.1806292exercisemean arterial pressurevascular impairmentarterial stiffnessurinary albumin excretion |
| spellingShingle | Nobuyuki Miyai Maki Shiozaki Kazufumi Terada Tatsuya Takeshita Miyoko Utsumi Kazuhisa Miyashita Mikio Arita Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals Clinical and Experimental Hypertension exercise mean arterial pressure vascular impairment arterial stiffness urinary albumin excretion |
| title | Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals |
| title_full | Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals |
| title_fullStr | Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals |
| title_full_unstemmed | Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals |
| title_short | Exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals |
| title_sort | exaggerated blood pressure response to exercise is associated with subclinical vascular impairment in healthy normotensive individuals |
| topic | exercise mean arterial pressure vascular impairment arterial stiffness urinary albumin excretion |
| url | http://dx.doi.org/10.1080/10641963.2020.1806292 |
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