Bradykinin and its role in osteoarthritis
Osteoarthritis (OA), the most common joint disorder, is a disease involving all the articular structures. It presents both degenerative and inflammatory aspects. Recently, the important role of Bradykinin (BK), a phlogistic mediator, has been proposed in the pathophysiology of OA. In our review, we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2013-07-01
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| Series: | Reumatismo |
| Subjects: | |
| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/670 |
| _version_ | 1818008067925606400 |
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| author | L. De Falco A. Fioravanti M. Galeazzi S. Tenti |
| author_facet | L. De Falco A. Fioravanti M. Galeazzi S. Tenti |
| author_sort | L. De Falco |
| collection | DOAJ |
| description | Osteoarthritis (OA), the most common joint disorder, is a disease involving all the articular structures. It presents both degenerative and inflammatory aspects. Recently, the important role of Bradykinin (BK), a phlogistic mediator, has been proposed in the pathophysiology of OA. In our review, we summarized the currently available information on the mechanisms of action of BK in OA by linking its B<sub>2</sub> receptors. Then, we analyzed the data about the effects of BK in synoviocytes and chondrocytes cultures. Furthermore, we described the action of B<sub>2</sub> receptor antagonists (Icatibant and Fasitibant), presenting them as new promising symptom-anddisease- modifying agents in the treatment of OA. However, more in vitro, animal model and clinical studies, are needed to better understand the mechanisms of action as well as the efficacy and tolerability of the B<sub>2</sub> receptor antagonists in OA. |
| first_indexed | 2024-04-14T05:24:18Z |
| format | Article |
| id | doaj.art-604beef6e9e241b38ba0a63bd22f6afd |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-04-14T05:24:18Z |
| publishDate | 2013-07-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-604beef6e9e241b38ba0a63bd22f6afd2022-12-22T02:10:02ZengPAGEPress PublicationsReumatismo0048-74492240-26832013-07-016539710410.4081/reumatismo.2013.97605Bradykinin and its role in osteoarthritisL. De Falco0A. Fioravanti1M. Galeazzi2S. Tenti3Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of SienaRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of SienaRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of SienaRheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of SienaOsteoarthritis (OA), the most common joint disorder, is a disease involving all the articular structures. It presents both degenerative and inflammatory aspects. Recently, the important role of Bradykinin (BK), a phlogistic mediator, has been proposed in the pathophysiology of OA. In our review, we summarized the currently available information on the mechanisms of action of BK in OA by linking its B<sub>2</sub> receptors. Then, we analyzed the data about the effects of BK in synoviocytes and chondrocytes cultures. Furthermore, we described the action of B<sub>2</sub> receptor antagonists (Icatibant and Fasitibant), presenting them as new promising symptom-anddisease- modifying agents in the treatment of OA. However, more in vitro, animal model and clinical studies, are needed to better understand the mechanisms of action as well as the efficacy and tolerability of the B<sub>2</sub> receptor antagonists in OA.http://www.reumatismo.org/index.php/reuma/article/view/670Bradykinin B2 receptor antagonists, Bradykinin, Fasitibant, Icatibant, osteoarthritis. |
| spellingShingle | L. De Falco A. Fioravanti M. Galeazzi S. Tenti Bradykinin and its role in osteoarthritis Reumatismo Bradykinin B2 receptor antagonists, Bradykinin, Fasitibant, Icatibant, osteoarthritis. |
| title | Bradykinin and its role in osteoarthritis |
| title_full | Bradykinin and its role in osteoarthritis |
| title_fullStr | Bradykinin and its role in osteoarthritis |
| title_full_unstemmed | Bradykinin and its role in osteoarthritis |
| title_short | Bradykinin and its role in osteoarthritis |
| title_sort | bradykinin and its role in osteoarthritis |
| topic | Bradykinin B2 receptor antagonists, Bradykinin, Fasitibant, Icatibant, osteoarthritis. |
| url | http://www.reumatismo.org/index.php/reuma/article/view/670 |
| work_keys_str_mv | AT ldefalco bradykininanditsroleinosteoarthritis AT afioravanti bradykininanditsroleinosteoarthritis AT mgaleazzi bradykininanditsroleinosteoarthritis AT stenti bradykininanditsroleinosteoarthritis |