Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma
Objective: To investigate the short-term efficacy and safety of different chemotherapy regimens combined with thalidomide, in the treatment of low-income patients with newly diagnosed HIV-associated diffuse large B-cell lymphoma. Methods: A retrospective analysis was performed on 42 patients with HI...
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| Format: | Article |
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Elsevier
2024-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048924000402 |
| _version_ | 1797261838070579200 |
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| author | Peng fei Tao Chuan Qian Qi wen zhou Sen Lin Dan qing Wang Xi Wang Shi fen Chen Hai yan Min |
| author_facet | Peng fei Tao Chuan Qian Qi wen zhou Sen Lin Dan qing Wang Xi Wang Shi fen Chen Hai yan Min |
| author_sort | Peng fei Tao |
| collection | DOAJ |
| description | Objective: To investigate the short-term efficacy and safety of different chemotherapy regimens combined with thalidomide, in the treatment of low-income patients with newly diagnosed HIV-associated diffuse large B-cell lymphoma. Methods: A retrospective analysis was performed on 42 patients with HIV-DLBCL who were admitted to the Infectious Diseases Department of Yunnan Provincial Infectious Diseases Hospital from January 2018 to December 2020. 14 cases (including 1 case in stage II and 13 cases in stage III/IV) were treated with R-CHOP, 24 cases (including 1 case in stage II and 23 cases in stage III/IV) were treated with R-DAEPOCH, and 4 cases (including 1 case in stage II and 3 cases in stage III/IV) were treated with EPOCH. All patients were treated with thalidomide. The ART regimen was adjusted. At least 1 and up to 6 intrathecal injections were given during chemotherapy, and cotrimoxazole was taken orally to prevent infection. The clinical efficacy was evaluated after 4 cycles of chemotherapy, and adverse events were evaluated at each cycle of chemotherapy. Results: All patients received 1–8 cycles of chemotherapy. CR (64.2 %) was achieved in 9 patients in R-CHOP group, and 5 patients died. In the R-DAEPOCH group, 17 patients achieved CR (70.8 %) and 7 died. In the EPOCH group, 2 patients reached CR (50 %) and 2 died. The main adverse reactions were grade II and above myelosuppression. Conclusion: Combined treatment with thalidomide can improve the prognosis of low-income patients with newly diagnosed HIV-DLBCL. |
| first_indexed | 2024-04-24T23:47:34Z |
| format | Article |
| id | doaj.art-604c1939e62d477584bce083d1bd4039 |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-04-24T23:47:34Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-604c1939e62d477584bce083d1bd40392024-03-15T04:43:23ZengElsevierLeukemia Research Reports2213-04892024-01-0121100450Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphomaPeng fei Tao0Chuan Qian1Qi wen zhou2Sen Lin3Dan qing Wang4Xi Wang5Shi fen Chen6Hai yan Min7Corresponding author.; Department of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaDepartment of Infectious Disease, Yun nan Provincial Infectious Disease Hospital 650301, ChinaObjective: To investigate the short-term efficacy and safety of different chemotherapy regimens combined with thalidomide, in the treatment of low-income patients with newly diagnosed HIV-associated diffuse large B-cell lymphoma. Methods: A retrospective analysis was performed on 42 patients with HIV-DLBCL who were admitted to the Infectious Diseases Department of Yunnan Provincial Infectious Diseases Hospital from January 2018 to December 2020. 14 cases (including 1 case in stage II and 13 cases in stage III/IV) were treated with R-CHOP, 24 cases (including 1 case in stage II and 23 cases in stage III/IV) were treated with R-DAEPOCH, and 4 cases (including 1 case in stage II and 3 cases in stage III/IV) were treated with EPOCH. All patients were treated with thalidomide. The ART regimen was adjusted. At least 1 and up to 6 intrathecal injections were given during chemotherapy, and cotrimoxazole was taken orally to prevent infection. The clinical efficacy was evaluated after 4 cycles of chemotherapy, and adverse events were evaluated at each cycle of chemotherapy. Results: All patients received 1–8 cycles of chemotherapy. CR (64.2 %) was achieved in 9 patients in R-CHOP group, and 5 patients died. In the R-DAEPOCH group, 17 patients achieved CR (70.8 %) and 7 died. In the EPOCH group, 2 patients reached CR (50 %) and 2 died. The main adverse reactions were grade II and above myelosuppression. Conclusion: Combined treatment with thalidomide can improve the prognosis of low-income patients with newly diagnosed HIV-DLBCL.http://www.sciencedirect.com/science/article/pii/S2213048924000402Different chemotherapy regimensThalidomideCombination therapyHiv-associated diffuse large b-cell lymphomaSecurityEffectiveness |
| spellingShingle | Peng fei Tao Chuan Qian Qi wen zhou Sen Lin Dan qing Wang Xi Wang Shi fen Chen Hai yan Min Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma Leukemia Research Reports Different chemotherapy regimens Thalidomide Combination therapy Hiv-associated diffuse large b-cell lymphoma Security Effectiveness |
| title | Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma |
| title_full | Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma |
| title_fullStr | Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma |
| title_full_unstemmed | Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma |
| title_short | Efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed HIV-associated diffuse large B-cell lymphoma |
| title_sort | efficacy and safety of different chemotherapy regimens combined with thalidomide in the treatment of diagnosed hiv associated diffuse large b cell lymphoma |
| topic | Different chemotherapy regimens Thalidomide Combination therapy Hiv-associated diffuse large b-cell lymphoma Security Effectiveness |
| url | http://www.sciencedirect.com/science/article/pii/S2213048924000402 |
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