Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress
Ischemic stroke, a cerebrovascular disease with high incidence, high mortality, high disability rate and high recurrence rate, is an important cause of death and disability of middle-aged and elderly people in China, and imposes a huge burden to society and families. Therefore, it is essential to id...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2024-03-01
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| Series: | Xiehe Yixue Zazhi |
| Subjects: | |
| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0452 |
| _version_ | 1797220262556467200 |
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| author | LIU Miaomiao YUE Hongmei LI Yating XU Jinhui WU Xingdong ZHU Haobin |
| author_facet | LIU Miaomiao YUE Hongmei LI Yating XU Jinhui WU Xingdong ZHU Haobin |
| author_sort | LIU Miaomiao |
| collection | DOAJ |
| description | Ischemic stroke, a cerebrovascular disease with high incidence, high mortality, high disability rate and high recurrence rate, is an important cause of death and disability of middle-aged and elderly people in China, and imposes a huge burden to society and families. Therefore, it is essential to identify the risk factors associated with ischemic stroke and effectively prevent them. Studies have shown that obstructive sleep apnea is an independent risk factor for ischemic stroke. However, the exact pathological mechanism of their association has not been clarified. With the development of next-generation sequencing technology, more and more studies have focused on intestinal microbiota. They have found that obstructive sleep apnea can cause intestinal microbiota changes, and intestinal microbiota may be closely related to ischemic stroke. Therefore, this paper attempts to investigate the relationship between intestinal flora and ischemic stroke, so as to reveal the potential pathological mechanism of ischemic stroke caused by obstructive sleep apnea. |
| first_indexed | 2024-04-24T12:46:45Z |
| format | Article |
| id | doaj.art-604d3c940d764d48806db327234d96e4 |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-04-24T12:46:45Z |
| publishDate | 2024-03-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-604d3c940d764d48806db327234d96e42024-04-07T00:51:22ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812024-03-0115238238610.12290/xhyxzz.2023-0452Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research ProgressLIU Miaomiao0YUE HongmeiLI Yating1XU Jinhui2WU Xingdong3ZHU Haobin4The First Clinical Medical School, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou 730000, ChinaIschemic stroke, a cerebrovascular disease with high incidence, high mortality, high disability rate and high recurrence rate, is an important cause of death and disability of middle-aged and elderly people in China, and imposes a huge burden to society and families. Therefore, it is essential to identify the risk factors associated with ischemic stroke and effectively prevent them. Studies have shown that obstructive sleep apnea is an independent risk factor for ischemic stroke. However, the exact pathological mechanism of their association has not been clarified. With the development of next-generation sequencing technology, more and more studies have focused on intestinal microbiota. They have found that obstructive sleep apnea can cause intestinal microbiota changes, and intestinal microbiota may be closely related to ischemic stroke. Therefore, this paper attempts to investigate the relationship between intestinal flora and ischemic stroke, so as to reveal the potential pathological mechanism of ischemic stroke caused by obstructive sleep apnea.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0452obstructive sleep apneaintestinal floraischemic strokerisk factorsshort-chain fatty acidstrimethylamine-n-oxide |
| spellingShingle | LIU Miaomiao YUE Hongmei LI Yating XU Jinhui WU Xingdong ZHU Haobin Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress Xiehe Yixue Zazhi obstructive sleep apnea intestinal flora ischemic stroke risk factors short-chain fatty acids trimethylamine-n-oxide |
| title | Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress |
| title_full | Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress |
| title_fullStr | Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress |
| title_full_unstemmed | Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress |
| title_short | Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress |
| title_sort | obstructive sleep apnea induced gut dysbiosis and ischaemic stroke mechanism and research progress |
| topic | obstructive sleep apnea intestinal flora ischemic stroke risk factors short-chain fatty acids trimethylamine-n-oxide |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2023-0452 |
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