Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation.
Diet-related metabolic syndrome is the largest contributor to adverse health in the United States. However, the study of gene-environment interactions and their epigenomic and transcriptomic integration is complicated by the lack of environmental and genetic control in humans that is possible in mou...
Main Authors: | Phillip Wulfridge, Adam Davidovich, Anna C Salvador, Gabrielle C Manno, Rakel Tryggvadottir, Adrian Idrizi, M Nazmul Huda, Brian J Bennett, L Garry Adams, Kasper D Hansen, David W Threadgill, Andrew P Feinberg |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-10-01
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Series: | PLoS Genetics |
Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010997&type=printable |
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