The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer
Prostate cancer (PCa) is one of the most common male malignancies with frequent remote invasion and metastasis, leading to high mortality. Epithelial-mesenchymal transition (EMT) is a fundamental process in embryonic development and plays a key role in tumor proliferation, invasion and metastasis. N...
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| Format: | Article |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.939070/full |
| _version_ | 1818097245485006848 |
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| author | Dexin Shen Dexin Shen Hongwei Peng Caixia Xia Zhao Deng Xi Tong Gang Wang Gang Wang Kaiyu Qian Kaiyu Qian Kaiyu Qian Kaiyu Qian |
| author_facet | Dexin Shen Dexin Shen Hongwei Peng Caixia Xia Zhao Deng Xi Tong Gang Wang Gang Wang Kaiyu Qian Kaiyu Qian Kaiyu Qian Kaiyu Qian |
| author_sort | Dexin Shen |
| collection | DOAJ |
| description | Prostate cancer (PCa) is one of the most common male malignancies with frequent remote invasion and metastasis, leading to high mortality. Epithelial-mesenchymal transition (EMT) is a fundamental process in embryonic development and plays a key role in tumor proliferation, invasion and metastasis. Numerous long non-coding RNAs (lncRNAs) could regulate the occurrence and development of EMT through various complex molecular mechanisms involving multiple signaling pathways in PCa. Given the importance of EMT and lncRNAs in the progression of tumor metastasis, we recapitulate the research progress of EMT-related signaling pathways regulated by lncRNAs in PCa, including AR signaling, STAT3 signaling, Wnt/β-catenin signaling, PTEN/PI3K/AKT signaling, TGF-β/Smad and NF-κB signaling pathways. Furthermore, we summarize four modes of how lncRNAs participate in the EMT process of PCa via regulating relevant signaling pathways. |
| first_indexed | 2024-12-10T23:17:27Z |
| format | Article |
| id | doaj.art-605020be761b4849af2dd3c02645122f |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-10T23:17:27Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-605020be761b4849af2dd3c02645122f2022-12-22T01:29:48ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-07-01910.3389/fmolb.2022.939070939070The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate CancerDexin Shen0Dexin Shen1Hongwei Peng2Caixia Xia3Zhao Deng4Xi Tong5Gang Wang6Gang Wang7Kaiyu Qian8Kaiyu Qian9Kaiyu Qian10Kaiyu Qian11Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaWuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, ChinaDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, ChinaPresident’s Office, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHuman Genetic Resource Preservation Center of Hubei Province, Wuhan, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaWuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, ChinaDepartment of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, ChinaHuman Genetic Resource Preservation Center of Hubei Province, Wuhan, ChinaProstate cancer (PCa) is one of the most common male malignancies with frequent remote invasion and metastasis, leading to high mortality. Epithelial-mesenchymal transition (EMT) is a fundamental process in embryonic development and plays a key role in tumor proliferation, invasion and metastasis. Numerous long non-coding RNAs (lncRNAs) could regulate the occurrence and development of EMT through various complex molecular mechanisms involving multiple signaling pathways in PCa. Given the importance of EMT and lncRNAs in the progression of tumor metastasis, we recapitulate the research progress of EMT-related signaling pathways regulated by lncRNAs in PCa, including AR signaling, STAT3 signaling, Wnt/β-catenin signaling, PTEN/PI3K/AKT signaling, TGF-β/Smad and NF-κB signaling pathways. Furthermore, we summarize four modes of how lncRNAs participate in the EMT process of PCa via regulating relevant signaling pathways.https://www.frontiersin.org/articles/10.3389/fmolb.2022.939070/fullprostate cancer (PCa)long non-coding RNA (lncRNA)epithelial-mesenchymal transition (EMT)androgen receptor (AR)wnt/β-catenin |
| spellingShingle | Dexin Shen Dexin Shen Hongwei Peng Caixia Xia Zhao Deng Xi Tong Gang Wang Gang Wang Kaiyu Qian Kaiyu Qian Kaiyu Qian Kaiyu Qian The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer Frontiers in Molecular Biosciences prostate cancer (PCa) long non-coding RNA (lncRNA) epithelial-mesenchymal transition (EMT) androgen receptor (AR) wnt/β-catenin |
| title | The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer |
| title_full | The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer |
| title_fullStr | The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer |
| title_full_unstemmed | The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer |
| title_short | The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer |
| title_sort | role of long non coding rnas in epithelial mesenchymal transition related signaling pathways in prostate cancer |
| topic | prostate cancer (PCa) long non-coding RNA (lncRNA) epithelial-mesenchymal transition (EMT) androgen receptor (AR) wnt/β-catenin |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.939070/full |
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