Role of Lung Function Genes in the Development of Asthma.
Although our previous GWAS failed to identify SNPs associated with pulmonary function at the level of genomewide significance, it did show that the heritability for FEV1/FVC was 41.6% in a Japanese population, suggesting that the heritability of pulmonary function traits can be explained by the addi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4709100?pdf=render |
| _version_ | 1818310191899213824 |
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| author | Hideyasu Yamada Hironori Masuko Yohei Yatagai Tohru Sakamoto Yoshiko Kaneko Hiroaki Iijima Takashi Naito Emiko Noguchi Satoshi Konno Masaharu Nishimura Tomomitsu Hirota Mayumi Tamari Nobuyuki Hizawa |
| author_facet | Hideyasu Yamada Hironori Masuko Yohei Yatagai Tohru Sakamoto Yoshiko Kaneko Hiroaki Iijima Takashi Naito Emiko Noguchi Satoshi Konno Masaharu Nishimura Tomomitsu Hirota Mayumi Tamari Nobuyuki Hizawa |
| author_sort | Hideyasu Yamada |
| collection | DOAJ |
| description | Although our previous GWAS failed to identify SNPs associated with pulmonary function at the level of genomewide significance, it did show that the heritability for FEV1/FVC was 41.6% in a Japanese population, suggesting that the heritability of pulmonary function traits can be explained by the additive effects of multiple common SNPs. In addition, our previous study indicated that pulmonary function genes identified in previous GWASs in non-Japanese populations accounted for 4.3% to 12.0% of the entire estimated heritability of FEV1/FVC in a Japanese population. Therefore, given that many loci with individual weak effects may contribute to asthma risk, in this study, we created a quantitative score of genetic load based on 16 SNPs implicated in lower lung function in both Japanese and non-Japanese populations. This genetic risk score (GRS) for lower FEV1/FVC was consistently associated with the onset of asthma (P = 9.6 × 10(-4)) in 2 independent Japanese populations as well as with the onset of COPD (P = 0.042). Clustering of asthma patients based on GRS levels indicated that an increased GRS may be responsible for the development of a particular phenotype of asthma characterized by early onset, atopy, and severer airflow obstruction. |
| first_indexed | 2024-12-13T07:42:09Z |
| format | Article |
| id | doaj.art-6051f1362d6b492fbc229f16f5c54811 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T07:42:09Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6051f1362d6b492fbc229f16f5c548112022-12-21T23:54:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014583210.1371/journal.pone.0145832Role of Lung Function Genes in the Development of Asthma.Hideyasu YamadaHironori MasukoYohei YatagaiTohru SakamotoYoshiko KanekoHiroaki IijimaTakashi NaitoEmiko NoguchiSatoshi KonnoMasaharu NishimuraTomomitsu HirotaMayumi TamariNobuyuki HizawaAlthough our previous GWAS failed to identify SNPs associated with pulmonary function at the level of genomewide significance, it did show that the heritability for FEV1/FVC was 41.6% in a Japanese population, suggesting that the heritability of pulmonary function traits can be explained by the additive effects of multiple common SNPs. In addition, our previous study indicated that pulmonary function genes identified in previous GWASs in non-Japanese populations accounted for 4.3% to 12.0% of the entire estimated heritability of FEV1/FVC in a Japanese population. Therefore, given that many loci with individual weak effects may contribute to asthma risk, in this study, we created a quantitative score of genetic load based on 16 SNPs implicated in lower lung function in both Japanese and non-Japanese populations. This genetic risk score (GRS) for lower FEV1/FVC was consistently associated with the onset of asthma (P = 9.6 × 10(-4)) in 2 independent Japanese populations as well as with the onset of COPD (P = 0.042). Clustering of asthma patients based on GRS levels indicated that an increased GRS may be responsible for the development of a particular phenotype of asthma characterized by early onset, atopy, and severer airflow obstruction.http://europepmc.org/articles/PMC4709100?pdf=render |
| spellingShingle | Hideyasu Yamada Hironori Masuko Yohei Yatagai Tohru Sakamoto Yoshiko Kaneko Hiroaki Iijima Takashi Naito Emiko Noguchi Satoshi Konno Masaharu Nishimura Tomomitsu Hirota Mayumi Tamari Nobuyuki Hizawa Role of Lung Function Genes in the Development of Asthma. PLoS ONE |
| title | Role of Lung Function Genes in the Development of Asthma. |
| title_full | Role of Lung Function Genes in the Development of Asthma. |
| title_fullStr | Role of Lung Function Genes in the Development of Asthma. |
| title_full_unstemmed | Role of Lung Function Genes in the Development of Asthma. |
| title_short | Role of Lung Function Genes in the Development of Asthma. |
| title_sort | role of lung function genes in the development of asthma |
| url | http://europepmc.org/articles/PMC4709100?pdf=render |
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