Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine

Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine

Anti-fibrotic therapies are of increasing interest to combat cardiac remodeling and heart failure progression. Recently, anti-fibrotic circular RNAs (circRNAs) have been identified in human and rodent cardiac tissue. In vivo (rodent) experiments proved cardiac anti-fibrotic effects of the natural co...

Full description

Bibliographic Details
Main Authors:	Julia Mester-Tonczar, Johannes Winkler, Patrick Einzinger, Ena Hasimbegovic, Nina Kastner, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Sandor Batkai, Thomas Thum, Mariann Gyöngyösi
Format:	Article
Language:	English
Published:	MDPI AG 2020-08-01
Series:	Biomolecules
Subjects:	cardiac fibrosis porcine model cardiovascular disease bufalin lycorine circular RNA
Online Access:	https://www.mdpi.com/2218-273X/10/8/1180

Similar Items

Uncover the anticancer potential of lycorine
by: Yan-Ming Zhang, et al.
Published: (2024-09-01)

New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA
by: Nina Kastner, et al.
Published: (2020-08-01)

Circular RNAs in Cardiac Regeneration: Cardiac Cell Proliferation, Differentiation, Survival, and Reprogramming
by: Julia Mester-Tonczar, et al.
Published: (2020-09-01)

Novel Lycorine Derivatives as Anticancer Agents: Synthesis and In Vitro Biological Evaluation
by: Peng Wang, et al.
Published: (2014-02-01)

Enhanced Intestinal Permeability of Bufalin by a Novel Bufalin-Peptide-Dendrimer Inclusion through Caco-2 Cell Monolayer
by: Chi-on Chan, et al.
Published: (2017-11-01)

Global trends in bufalin application research for cancer from 2003 to 2022: A bibliometric and visualised analysis
by: Donghao Tang, et al.
Published: (2024-01-01)

Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase
by: Wang Yue-Hu, et al.
Published: (2012-09-01)

A CircRNA–miRNA–mRNA Network for Exploring Doxorubicin- and Myocet-Induced Cardiotoxicity in a Translational Porcine Model
by: Julia Mester-Tonczar, et al.
Published: (2023-11-01)

Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS
by: Wenlong Wei, et al.
Published: (2019-04-01)

Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes
by: Jiani Yuan, et al.
Published: (2017-11-01)

Large Animal Models of Cell-Free Cardiac Regeneration
by: Andreas Spannbauer, et al.
Published: (2020-09-01)

Bufalin reverses ABCB1-mediated resistance to docetaxel in breast cancer
by: Die Zhang, et al.
Published: (2023-03-01)

Bufalin inhibits the growth and epithelial to mesenchymal transition of human gastric cancer cells via modulation of MEK/ERK pathway
by: Yi Zhou, et al.
Published: (2021-01-01)

Lycorine combined with cisplatin synergistically inhibited osteosarcoma cells growth and metastasis by suppressing Wnt/β-Catenin and STAT3 signaling pathways
by: Xuexue Liu, et al.
Published: (2024-08-01)

Spatial Lipidomics Reveals Anticancer Mechanisms of Bufalin in Combination with Cinobufagin in Tumor-Bearing Mice
by: Jinghui Zhang, et al.
Published: (2021-01-01)

Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication
by: Qin Chuan, et al.
Published: (2011-10-01)

Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis
by: Yunxian Dong, et al.
Published: (2022-05-01)

Bufalin-Loaded PEGylated Liposomes: Antitumor Efficacy, Acute Toxicity, and Tissue Distribution
by: Jiani Yuan, et al.
Published: (2019-07-01)

Lycorine Ameliorates Thioacetamide-Induced Hepatic Fibrosis in Rats: Emphasis on Antioxidant, Anti-Inflammatory, and STAT3 Inhibition Effects
by: Huda Mohammed Alkreathy, et al.
Published: (2022-03-01)

Exploration of Lycorine and Copper(II)’s Association with the N-Terminal Domain of Amyloid β
by: Arian Kola, et al.
Published: (2023-11-01)

Surfactant Assisted Rapid-Release Liposomal Strategies Enhance the Antitumor Efficiency of Bufalin Derivative and Reduce Cardiotoxicity
by: Gao L, et al.
Published: (2021-05-01)

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway
by: Kai Fang, et al.
Published: (2021-09-01)

An overview of the past decade of bufalin in the treatment of refractory and drug-resistant cancers: current status, challenges, and future perspectives
by: Qingmei Ye, et al.
Published: (2023-10-01)

New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin
by: Chien-shan Cheng, et al.
Published: (2019-04-01)

Bufalin CaCO3 nanoparticles triggered pyroptosis through calcium overload via Na+/Ca2+ exchanger reverse for cancer immunotherapy
by: Li, Tingxuan, et al.
Published: (2025)

Bufalin Inhibits hTERT Expression and Colorectal Cancer Cell Growth by Targeting CPSF4
by: Ningning Zhang, et al.
Published: (2016-12-01)

Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress
by: Hongyan Zhao, et al.
Published: (2017-10-01)

Lycorine hydrochloride inhibits the proliferation, migration and invasion of gastric cancer cell line MGC-803
by: BAO Mei-mei, XU Wen, WANG Chao, WANG Jia, MIAO Xiao-fen
Published: (2021-12-01)

Lycorine inhibits angiogenesis by docking to PDGFRα
by: Fei Lv, et al.
Published: (2022-08-01)

Rod-shaped mesoporous silica nanoparticles reduce bufalin cardiotoxicity and inhibit colon cancer by blocking lipophagy
by: Yibao Fan, et al.
Published: (2024-09-01)

Development of octreotide-conjugated polymeric prodrug of bufalin for targeted delivery to somatostatin receptor 2 overexpressing breast cancer in vitro and in vivo
by: Liu T, et al.
Published: (2016-05-01)

Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a
by: Yuewen Chang, et al.
Published: (2015-06-01)

Determination of Endogenous Bufalin in Serum of Patients With Hepatocellular Carcinoma Based on HPLC-MS/MS
by: Mengfei Han, et al.
Published: (2020-01-01)

Bufalin-Mediated Regulation of Cell Signaling Pathways in Different Cancers: Spotlight on JAK/STAT, Wnt/β-Catenin, mTOR, TRAIL/TRAIL-R, and Non-Coding RNAs
by: Ammad Ahmad Farooqi, et al.
Published: (2023-02-01)

Antiviral and virucidal activities of lycorine on duck tembusu virus in vitro by blocking viral internalization and entry
by: Xuan Lv, et al.
Published: (2021-10-01)

Effect of Bufalin on Proliferation and Apoptosis of Human Non-small Cell Lung Cancer A549 Cell
by: Zhitu ZHU, et al.
Published: (2010-09-01)

Preparation and Evaluation of Folate Modified PEG-PLLA Nanoparticles Loaded with Lycorine for Glioma Treatment
by: Jieqiong Ding, et al.
Published: (2024-02-01)

Apoptosis Induction of Lycorine on Lung Cancer NCI-H460 Cells and Related Mechanism
by: LI Juwei, et al.
Published: (2018-01-01)

Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis
by: Jing Wen, et al.
Published: (2024-12-01)

Lycorine weakens tamoxifen resistance of breast cancer via abrogating HAGLR‐mediated epigenetic suppression on VGLL4 by DNMT1
by: Jing Zhai, et al.
Published: (2023-03-01)