Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier
Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bact...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15999-y |
| _version_ | 1818683086645231616 |
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| author | Valerie Cortez David F. Boyd Jeremy Chase Crawford Bridgett Sharp Brandi Livingston Hannah M. Rowe Amy Davis Ramzi Alsallaq Camenzind G. Robinson Peter Vogel Jason W. Rosch Elisa Margolis Paul G. Thomas Stacey Schultz-Cherry |
| author_facet | Valerie Cortez David F. Boyd Jeremy Chase Crawford Bridgett Sharp Brandi Livingston Hannah M. Rowe Amy Davis Ramzi Alsallaq Camenzind G. Robinson Peter Vogel Jason W. Rosch Elisa Margolis Paul G. Thomas Stacey Schultz-Cherry |
| author_sort | Valerie Cortez |
| collection | DOAJ |
| description | Astroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut. |
| first_indexed | 2024-12-17T10:29:09Z |
| format | Article |
| id | doaj.art-6053f463514e437bb5ee437308a9eef9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:29:09Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6053f463514e437bb5ee437308a9eef92022-12-21T21:52:35ZengNature PortfolioNature Communications2041-17232020-04-011111910.1038/s41467-020-15999-yAstrovirus infects actively secreting goblet cells and alters the gut mucus barrierValerie Cortez0David F. Boyd1Jeremy Chase Crawford2Bridgett Sharp3Brandi Livingston4Hannah M. Rowe5Amy Davis6Ramzi Alsallaq7Camenzind G. Robinson8Peter Vogel9Jason W. Rosch10Elisa Margolis11Paul G. Thomas12Stacey Schultz-Cherry13Department of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Immunology, St. Jude Children’s Research HospitalDepartment of Immunology, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalCell and Tissue Imaging Center, St. Jude Children’s Research HospitalVeterinary Pathology Core, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalDepartment of Immunology, St. Jude Children’s Research HospitalDepartment of Infectious Diseases, St. Jude Children’s Research HospitalAstroviruses are the leading cause of pediatric diarrhea, but which cells are the main targets in the gut remains unclear. Here, using an in vivo model of murine astrovirus, the authors show that the virus infects goblet cells and that this alters mucus production and increases mucus-associated bacterial communities in the gut.https://doi.org/10.1038/s41467-020-15999-y |
| spellingShingle | Valerie Cortez David F. Boyd Jeremy Chase Crawford Bridgett Sharp Brandi Livingston Hannah M. Rowe Amy Davis Ramzi Alsallaq Camenzind G. Robinson Peter Vogel Jason W. Rosch Elisa Margolis Paul G. Thomas Stacey Schultz-Cherry Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier Nature Communications |
| title | Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier |
| title_full | Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier |
| title_fullStr | Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier |
| title_full_unstemmed | Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier |
| title_short | Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier |
| title_sort | astrovirus infects actively secreting goblet cells and alters the gut mucus barrier |
| url | https://doi.org/10.1038/s41467-020-15999-y |
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