AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

Drug resistance is the main obstacle in the improvement of chemotherapeutic efficacy in glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA), one kind of androgen/neurosteroid, potentiates glioblastoma to acquire resistance through attenuating DNA damage. Androgen receptor (AR) act...

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Bibliographic Details
Main Authors: Tzu-Chi Chen, Jian-Ying Chuang, Chiung-Yuan Ko, Tzu-Jen Kao, Pei-Yu Yang, Chun-Hui Yu, Ming-Sheng Liu, Siou-Lian Hu, Yu-Ting Tsai, Hardy Chan, Wen-Chang Chang, Tsung-I. Hsu
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719311401

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