Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium

Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium

Normal function of the retinal pigment epithelium (RPE) is essential for maintaining the structural integrity of retinal photoreceptors and the visual process. Sustained oxidative damage of the RPE due to aging and other risk factors contributes to the development of age-related macular degeneration...

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Bibliographic Details
Main Authors: Chen Chen, Yimin Zhong, Joshua J. Wang, Qiang Yu, Kendra Plafker, Scott Plafker, Sarah X. Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Genetics
Subjects:
retinal pigment epithelium
NF-E2-related factor 2
X-box binding protein 1
endoplasmic reticulum stress
oxidative stress
cell death
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00658/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00658/full

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