Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer
Prostate cancer (PCa) is the most common male malignancy and the fifth leading cause of cancer death in men worldwide. Prostate cancer cells are characterized by a hybrid glycolytic/oxidative phosphorylation phenotype determined by androgen receptor signaling. An increased lipogenesis and cholestero...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/910 |
| _version_ | 1797441681573806080 |
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| author | Francesco Lasorsa Nicola Antonio di Meo Monica Rutigliano Matteo Ferro Daniela Terracciano Octavian Sabin Tataru Michele Battaglia Pasquale Ditonno Giuseppe Lucarelli |
| author_facet | Francesco Lasorsa Nicola Antonio di Meo Monica Rutigliano Matteo Ferro Daniela Terracciano Octavian Sabin Tataru Michele Battaglia Pasquale Ditonno Giuseppe Lucarelli |
| author_sort | Francesco Lasorsa |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most common male malignancy and the fifth leading cause of cancer death in men worldwide. Prostate cancer cells are characterized by a hybrid glycolytic/oxidative phosphorylation phenotype determined by androgen receptor signaling. An increased lipogenesis and cholesterogenesis have been described in PCa cells. Many studies have shown that enzymes involved in these pathways are overexpressed in PCa. Glutamine becomes an essential amino acid for PCa cells, and its metabolism is thought to become an attractive therapeutic target. A crosstalk between cancer and stromal cells occurs in the tumor microenvironment because of the release of different cytokines and growth factors and due to changes in the extracellular matrix. A deeper insight into the metabolic changes may be obtained by a multi-omic approach integrating genomics, transcriptomics, metabolomics, lipidomics, and radiomics data. |
| first_indexed | 2024-03-09T12:27:40Z |
| format | Article |
| id | doaj.art-6056739636824dc3a2590a45b98210af |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:27:40Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6056739636824dc3a2590a45b98210af2023-11-30T22:32:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-0124291010.3390/ijms24020910Emerging Hallmarks of Metabolic Reprogramming in Prostate CancerFrancesco Lasorsa0Nicola Antonio di Meo1Monica Rutigliano2Matteo Ferro3Daniela Terracciano4Octavian Sabin Tataru5Michele Battaglia6Pasquale Ditonno7Giuseppe Lucarelli8Urology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyDivision of Urology, European Institute of Oncology, IRCCS, 20141 Milan, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, 80131 Naples, ItalyThe Institution Organizing University Doctoral Studies (I.O.S.U.D.), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Târgu Mureș, RomaniaUrology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyProstate cancer (PCa) is the most common male malignancy and the fifth leading cause of cancer death in men worldwide. Prostate cancer cells are characterized by a hybrid glycolytic/oxidative phosphorylation phenotype determined by androgen receptor signaling. An increased lipogenesis and cholesterogenesis have been described in PCa cells. Many studies have shown that enzymes involved in these pathways are overexpressed in PCa. Glutamine becomes an essential amino acid for PCa cells, and its metabolism is thought to become an attractive therapeutic target. A crosstalk between cancer and stromal cells occurs in the tumor microenvironment because of the release of different cytokines and growth factors and due to changes in the extracellular matrix. A deeper insight into the metabolic changes may be obtained by a multi-omic approach integrating genomics, transcriptomics, metabolomics, lipidomics, and radiomics data.https://www.mdpi.com/1422-0067/24/2/910prostate cancermetabolomicsandrogen receptorbiomarkersmetastasiscastration resistance |
| spellingShingle | Francesco Lasorsa Nicola Antonio di Meo Monica Rutigliano Matteo Ferro Daniela Terracciano Octavian Sabin Tataru Michele Battaglia Pasquale Ditonno Giuseppe Lucarelli Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer International Journal of Molecular Sciences prostate cancer metabolomics androgen receptor biomarkers metastasis castration resistance |
| title | Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer |
| title_full | Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer |
| title_fullStr | Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer |
| title_full_unstemmed | Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer |
| title_short | Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer |
| title_sort | emerging hallmarks of metabolic reprogramming in prostate cancer |
| topic | prostate cancer metabolomics androgen receptor biomarkers metastasis castration resistance |
| url | https://www.mdpi.com/1422-0067/24/2/910 |
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