Viral hemorrhagic fevers: advancing the level of treatment
<p>Abstract</p> <p>The management of viral hemorrhagic fevers (VHFs) has mainly focused on strict infection control measures, while standard clinical interventions that are provided to patients with other life-threatening conditions are rarely offered to patients with VHFs. Despite...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-03-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1741-7015/10/31 |
| _version_ | 1819085615137816576 |
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| author | Ippolito Giuseppe Feldmann Heinz Lanini Simone Vairo Francesco Di Caro Antonino Capobianchi Maria Nicastri Emanuele |
| author_facet | Ippolito Giuseppe Feldmann Heinz Lanini Simone Vairo Francesco Di Caro Antonino Capobianchi Maria Nicastri Emanuele |
| author_sort | Ippolito Giuseppe |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The management of viral hemorrhagic fevers (VHFs) has mainly focused on strict infection control measures, while standard clinical interventions that are provided to patients with other life-threatening conditions are rarely offered to patients with VHFs. Despite its complexity, a proper clinical case management of VHFs is neither futile nor is it lacking in scientific rationale. Given that patient outcomes improve when treatment is started as soon as possible, development and implementation of protocols to promptly identify and treat patients in the earliest phases of diseases are urgently needed. Different pharmacological options have been proposed to manage patients and, as for other life-threatening conditions, advanced life support has been proved effective to address multiorgan failure. In addition, high throughput screening of small molecular libraries has emerged as a novel promising way to find new candidates drugs for VHFs therapy and a relevant number of new molecules are currently under investigation. Here we discuss the current knowledge about VHF clinical management to propose a way to step up the approach to VHFs beyond the mere application of infection control measures.</p> |
| first_indexed | 2024-12-21T21:07:10Z |
| format | Article |
| id | doaj.art-6056c3de53c24d6cb89abcbb2d5e2be0 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-21T21:07:10Z |
| publishDate | 2012-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-6056c3de53c24d6cb89abcbb2d5e2be02022-12-21T18:50:14ZengBMCBMC Medicine1741-70152012-03-011013110.1186/1741-7015-10-31Viral hemorrhagic fevers: advancing the level of treatmentIppolito GiuseppeFeldmann HeinzLanini SimoneVairo FrancescoDi Caro AntoninoCapobianchi MariaNicastri Emanuele<p>Abstract</p> <p>The management of viral hemorrhagic fevers (VHFs) has mainly focused on strict infection control measures, while standard clinical interventions that are provided to patients with other life-threatening conditions are rarely offered to patients with VHFs. Despite its complexity, a proper clinical case management of VHFs is neither futile nor is it lacking in scientific rationale. Given that patient outcomes improve when treatment is started as soon as possible, development and implementation of protocols to promptly identify and treat patients in the earliest phases of diseases are urgently needed. Different pharmacological options have been proposed to manage patients and, as for other life-threatening conditions, advanced life support has been proved effective to address multiorgan failure. In addition, high throughput screening of small molecular libraries has emerged as a novel promising way to find new candidates drugs for VHFs therapy and a relevant number of new molecules are currently under investigation. Here we discuss the current knowledge about VHF clinical management to propose a way to step up the approach to VHFs beyond the mere application of infection control measures.</p>http://www.biomedcentral.com/1741-7015/10/31clinical managementinnovative therapeuticsviral hemorrhagic fever |
| spellingShingle | Ippolito Giuseppe Feldmann Heinz Lanini Simone Vairo Francesco Di Caro Antonino Capobianchi Maria Nicastri Emanuele Viral hemorrhagic fevers: advancing the level of treatment BMC Medicine clinical management innovative therapeutics viral hemorrhagic fever |
| title | Viral hemorrhagic fevers: advancing the level of treatment |
| title_full | Viral hemorrhagic fevers: advancing the level of treatment |
| title_fullStr | Viral hemorrhagic fevers: advancing the level of treatment |
| title_full_unstemmed | Viral hemorrhagic fevers: advancing the level of treatment |
| title_short | Viral hemorrhagic fevers: advancing the level of treatment |
| title_sort | viral hemorrhagic fevers advancing the level of treatment |
| topic | clinical management innovative therapeutics viral hemorrhagic fever |
| url | http://www.biomedcentral.com/1741-7015/10/31 |
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