Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review
Abstract Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years. Biodegradable synthetic polymers are increasingly needed as transient substrates for tissue regeneration and medicine delivery. In...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-04-01
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| Series: | Macromolecular Materials and Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mame.202200553 |
| _version_ | 1797743171308879872 |
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| author | Pradeep Ilayaperumal Praveena Chelladurai Karthik Vairan Pooja Anilkumar Balajothi Balagurusamy |
| author_facet | Pradeep Ilayaperumal Praveena Chelladurai Karthik Vairan Pooja Anilkumar Balajothi Balagurusamy |
| author_sort | Pradeep Ilayaperumal |
| collection | DOAJ |
| description | Abstract Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years. Biodegradable synthetic polymers are increasingly needed as transient substrates for tissue regeneration and medicine delivery. In contrast to commonly used polymers including polyesters, polylactones, polyanhydrides, poly(propylene fumarates), polyorthoesters, and polyurethanes, biodegradable polyphosphazenes (PPZs) hold great potential for the purposes indicated above. PPZ's versatility in the synthetic process has enabled the production of a variety of polymers with various physico‐chemical, and biological properties have been produced, making them appropriate for biomedical applications. Biocompatible PPZs are often used as scaffolds in the regeneration of skeleton, bones, and other tissues. PPZs have also received special attention as potential drug vehicles of high‐value biopharmaceuticals such as anticancer drugs. Additionally, by incorporating fluorophores into the PPZ backbone to produce photoluminescent biodegradable PPZs, the utility of polyphosphazenes is further expanded as they are used in tracking the regeneration of the target tissue as well as the fate of PPZ based scaffolds or drug delivery vehicles. This review provides a summary of the evolution of PPZ applications in the fields of tissue engineering, drug delivery, and bioimaging in recent 5 years. |
| first_indexed | 2024-03-12T14:51:41Z |
| format | Article |
| id | doaj.art-60573363ac7645829d964caa94e44d48 |
| institution | Directory Open Access Journal |
| issn | 1438-7492 1439-2054 |
| language | English |
| last_indexed | 2024-03-12T14:51:41Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj.art-60573363ac7645829d964caa94e44d482023-08-15T09:10:27ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542023-04-013084n/an/a10.1002/mame.202200553Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A ReviewPradeep Ilayaperumal0Praveena Chelladurai1Karthik Vairan2Pooja Anilkumar3Balajothi Balagurusamy4Department of Chemistry Bishop Heber College Trichy Tamil Nadu 620017 IndiaDepartment of Chemistry Bishop Heber College Trichy Tamil Nadu 620017 IndiaDepartment of Chemistry Bishop Heber College Trichy Tamil Nadu 620017 IndiaSchool of Biotechnology National Institute of Technology Calicut Calicut Kerala 673601 IndiaDepartment of Chemistry Bishop Heber College Trichy Tamil Nadu 620017 IndiaAbstract Synthetic polymer materials have been surged to the forefront of research in the fields of tissue engineering, drug delivery, and biomonitoring in recent years. Biodegradable synthetic polymers are increasingly needed as transient substrates for tissue regeneration and medicine delivery. In contrast to commonly used polymers including polyesters, polylactones, polyanhydrides, poly(propylene fumarates), polyorthoesters, and polyurethanes, biodegradable polyphosphazenes (PPZs) hold great potential for the purposes indicated above. PPZ's versatility in the synthetic process has enabled the production of a variety of polymers with various physico‐chemical, and biological properties have been produced, making them appropriate for biomedical applications. Biocompatible PPZs are often used as scaffolds in the regeneration of skeleton, bones, and other tissues. PPZs have also received special attention as potential drug vehicles of high‐value biopharmaceuticals such as anticancer drugs. Additionally, by incorporating fluorophores into the PPZ backbone to produce photoluminescent biodegradable PPZs, the utility of polyphosphazenes is further expanded as they are used in tracking the regeneration of the target tissue as well as the fate of PPZ based scaffolds or drug delivery vehicles. This review provides a summary of the evolution of PPZ applications in the fields of tissue engineering, drug delivery, and bioimaging in recent 5 years.https://doi.org/10.1002/mame.202200553biodegradable scaffoldsbioimagingdrug deliverypolyphosphazenetissue engineering |
| spellingShingle | Pradeep Ilayaperumal Praveena Chelladurai Karthik Vairan Pooja Anilkumar Balajothi Balagurusamy Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review Macromolecular Materials and Engineering biodegradable scaffolds bioimaging drug delivery polyphosphazene tissue engineering |
| title | Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review |
| title_full | Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review |
| title_fullStr | Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review |
| title_full_unstemmed | Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review |
| title_short | Polyphosphazenes—A Promising Candidate for Drug Delivery, Bioimaging, and Tissue Engineering: A Review |
| title_sort | polyphosphazenes a promising candidate for drug delivery bioimaging and tissue engineering a review |
| topic | biodegradable scaffolds bioimaging drug delivery polyphosphazene tissue engineering |
| url | https://doi.org/10.1002/mame.202200553 |
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