Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study
Chronic excessive alcohol use has neurotoxic effects, which may contribute to cognitive decline and the risk of early-onset dementia. Elevated peripheral iron levels have been reported in individuals with alcohol use disorder (AUD), but its association with brain iron loading has not been explored....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4461 |
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| author | Aiden R. Adams Xinyi Li Juliana I. Byanyima Sianneh A. Vesslee Thanh D. Nguyen Yi Wang Brianna Moon Timothy Pond Henry R. Kranzler Walter R. Witschey Zhenhao Shi Corinde E. Wiers |
| author_facet | Aiden R. Adams Xinyi Li Juliana I. Byanyima Sianneh A. Vesslee Thanh D. Nguyen Yi Wang Brianna Moon Timothy Pond Henry R. Kranzler Walter R. Witschey Zhenhao Shi Corinde E. Wiers |
| author_sort | Aiden R. Adams |
| collection | DOAJ |
| description | Chronic excessive alcohol use has neurotoxic effects, which may contribute to cognitive decline and the risk of early-onset dementia. Elevated peripheral iron levels have been reported in individuals with alcohol use disorder (AUD), but its association with brain iron loading has not been explored. We evaluated whether (1) serum and brain iron loading are higher in individuals with AUD than non-dependent healthy controls and (2) serum and brain iron loading increase with age. A fasting serum iron panel was obtained and a magnetic resonance imaging scan with quantitative susceptibility mapping (QSM) was used to quantify brain iron concentrations. Although serum ferritin levels were higher in the AUD group than in controls, whole-brain iron susceptibility did not differ between groups. Voxel-wise QSM analyses revealed higher susceptibility in a cluster in the left globus pallidus in individuals with AUD than controls. Whole-brain iron increased with age and voxel-wise QSM indicated higher susceptibility with age in various brain areas including the basal ganglia. This is the first study to analyze both serum and brain iron loading in individuals with AUD. Larger studies are needed to examine the effects of alcohol use on iron loading and its associations with alcohol use severity, structural and functional brain changes, and alcohol-induced cognitive impairments. |
| first_indexed | 2024-03-11T07:23:33Z |
| format | Article |
| id | doaj.art-60576f48fbe04154ab003aaa798a0c7b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:23:33Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-60576f48fbe04154ab003aaa798a0c7b2023-11-17T07:48:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245446110.3390/ijms24054461Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot StudyAiden R. Adams0Xinyi Li1Juliana I. Byanyima2Sianneh A. Vesslee3Thanh D. Nguyen4Yi Wang5Brianna Moon6Timothy Pond7Henry R. Kranzler8Walter R. Witschey9Zhenhao Shi10Corinde E. Wiers11Center for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USADepartment of Radiology, Weill Cornell Medicine, 525 E 68th St, New York, NY 10065, USADepartment of Radiology, Weill Cornell Medicine, 525 E 68th St, New York, NY 10065, USADepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USADepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, South Pavilion, Room 11-155, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USACenter for Studies of Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St Ste 500, Philadelphia, PA 19104, USAChronic excessive alcohol use has neurotoxic effects, which may contribute to cognitive decline and the risk of early-onset dementia. Elevated peripheral iron levels have been reported in individuals with alcohol use disorder (AUD), but its association with brain iron loading has not been explored. We evaluated whether (1) serum and brain iron loading are higher in individuals with AUD than non-dependent healthy controls and (2) serum and brain iron loading increase with age. A fasting serum iron panel was obtained and a magnetic resonance imaging scan with quantitative susceptibility mapping (QSM) was used to quantify brain iron concentrations. Although serum ferritin levels were higher in the AUD group than in controls, whole-brain iron susceptibility did not differ between groups. Voxel-wise QSM analyses revealed higher susceptibility in a cluster in the left globus pallidus in individuals with AUD than controls. Whole-brain iron increased with age and voxel-wise QSM indicated higher susceptibility with age in various brain areas including the basal ganglia. This is the first study to analyze both serum and brain iron loading in individuals with AUD. Larger studies are needed to examine the effects of alcohol use on iron loading and its associations with alcohol use severity, structural and functional brain changes, and alcohol-induced cognitive impairments.https://www.mdpi.com/1422-0067/24/5/4461ironferritinalcohol use disorderquantitative susceptibility mapping |
| spellingShingle | Aiden R. Adams Xinyi Li Juliana I. Byanyima Sianneh A. Vesslee Thanh D. Nguyen Yi Wang Brianna Moon Timothy Pond Henry R. Kranzler Walter R. Witschey Zhenhao Shi Corinde E. Wiers Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study International Journal of Molecular Sciences iron ferritin alcohol use disorder quantitative susceptibility mapping |
| title | Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study |
| title_full | Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study |
| title_fullStr | Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study |
| title_full_unstemmed | Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study |
| title_short | Peripheral and Central Iron Measures in Alcohol Use Disorder and Aging: A Quantitative Susceptibility Mapping Pilot Study |
| title_sort | peripheral and central iron measures in alcohol use disorder and aging a quantitative susceptibility mapping pilot study |
| topic | iron ferritin alcohol use disorder quantitative susceptibility mapping |
| url | https://www.mdpi.com/1422-0067/24/5/4461 |
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