Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews
Abstract Background The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illegal opioids are at an increased risk of OUAIs compared to individuals no...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Systematic Reviews |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13643-021-01852-w |
| _version_ | 1819198976075759616 |
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| author | Irina Kudrina Svetlana Puzhko Kristian B. Filion Genevieve Gore Elena Paraskevopoulos Sarah Windle Marc O. Martel Mark J. Eisenberg |
| author_facet | Irina Kudrina Svetlana Puzhko Kristian B. Filion Genevieve Gore Elena Paraskevopoulos Sarah Windle Marc O. Martel Mark J. Eisenberg |
| author_sort | Irina Kudrina |
| collection | DOAJ |
| description | Abstract Background The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illegal opioids are at an increased risk of OUAIs compared to individuals not using opioids. As reported for hepatitis C virus (HCV), human immunodeficiency virus (HIV), bacterial, fungal, and other infections, OUAIs transmission and acquisition risks may be modifiable. Several systematic reviews (SRs) synthetized data regarding interventions to prevent infections in persons using drugs (e.g., opioid substitution therapy, needle and syringes exchange programs, psycho-social interventions); however, their conclusions varied. Therefore, SR of published SRs is needed to synthesize the highest level of evidence on the scope and effectiveness of interventions to prevent OUAIs in people using opioids legally or illegally. Methods We will comprehensively search for SRs in the PubMed, Embase, PsycINFO, Cochrane Database of Systematic Reviews, Epistemonikos, and Google Scholar databases from inception to November 2020. Data selection and extraction for each SR will be performed independently by two researchers, with disagreements resolved by consensus. All SRs regarding interventions with evaluated effectiveness to prevent OUAI in legal and/or illegal opioid users will be eligible. Risk of bias assessment will be performed using the AMSTAR2 tool. The results will be qualitatively synthesized, and a typology of interventions’ effectiveness with a statement on the strength of evidence for each category will be created. Discussion Our pilot search of PubMed resulted in 379 SRs analyzing the effectiveness of interventions to prevent HCV and HIV in persons who inject different types of drugs, including opioids. Of these 379 SRs, 8 evaluated primary studies where participants used opioids and would therefore be eligible for inclusion. The search results thus justify the application of SR of SRs approach. Comprehensive data on the scope and effectiveness of existing interventions to prevent OUAIs will help policy-makers to plan and implement preventive interventions and will assist clinicians in the guidance for their patients using opioids. Systematic review registration Registered in PROSPERO on 30 July 2020 ( #195929 ). |
| first_indexed | 2024-12-23T03:08:59Z |
| format | Article |
| id | doaj.art-6057b25bf73b497b8c0a75451669db0c |
| institution | Directory Open Access Journal |
| issn | 2046-4053 |
| language | English |
| last_indexed | 2024-12-23T03:08:59Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Systematic Reviews |
| spelling | doaj.art-6057b25bf73b497b8c0a75451669db0c2022-12-21T18:02:16ZengBMCSystematic Reviews2046-40532021-11-011011810.1186/s13643-021-01852-wEffectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviewsIrina Kudrina0Svetlana Puzhko1Kristian B. Filion2Genevieve Gore3Elena Paraskevopoulos4Sarah Windle5Marc O. Martel6Mark J. Eisenberg7Department of Family Medicine, Faculty of Medicine and Health Sciences, McGill UniversityDepartment of Family Medicine, Faculty of Medicine and Health Sciences, McGill UniversityDepartment of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill UniversitySchulich Library of Physical Sciences, Life Sciences, and Engineering, McGill UniversityDepartment of Family Medicine, Faculty of Medicine and Health Sciences, McGill UniversityDepartment of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill UniversityDepartment of Anesthesia, Faculty of Medicine and Health Sciences, McGill UniversityDepartment of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill UniversityAbstract Background The North American opioid crisis is driven by opioid-related mortality and morbidity, including opioid use-associated infections (OUAIs), resulting in a substantial burden for society. Users of legal and illegal opioids are at an increased risk of OUAIs compared to individuals not using opioids. As reported for hepatitis C virus (HCV), human immunodeficiency virus (HIV), bacterial, fungal, and other infections, OUAIs transmission and acquisition risks may be modifiable. Several systematic reviews (SRs) synthetized data regarding interventions to prevent infections in persons using drugs (e.g., opioid substitution therapy, needle and syringes exchange programs, psycho-social interventions); however, their conclusions varied. Therefore, SR of published SRs is needed to synthesize the highest level of evidence on the scope and effectiveness of interventions to prevent OUAIs in people using opioids legally or illegally. Methods We will comprehensively search for SRs in the PubMed, Embase, PsycINFO, Cochrane Database of Systematic Reviews, Epistemonikos, and Google Scholar databases from inception to November 2020. Data selection and extraction for each SR will be performed independently by two researchers, with disagreements resolved by consensus. All SRs regarding interventions with evaluated effectiveness to prevent OUAI in legal and/or illegal opioid users will be eligible. Risk of bias assessment will be performed using the AMSTAR2 tool. The results will be qualitatively synthesized, and a typology of interventions’ effectiveness with a statement on the strength of evidence for each category will be created. Discussion Our pilot search of PubMed resulted in 379 SRs analyzing the effectiveness of interventions to prevent HCV and HIV in persons who inject different types of drugs, including opioids. Of these 379 SRs, 8 evaluated primary studies where participants used opioids and would therefore be eligible for inclusion. The search results thus justify the application of SR of SRs approach. Comprehensive data on the scope and effectiveness of existing interventions to prevent OUAIs will help policy-makers to plan and implement preventive interventions and will assist clinicians in the guidance for their patients using opioids. Systematic review registration Registered in PROSPERO on 30 July 2020 ( #195929 ).https://doi.org/10.1186/s13643-021-01852-wOverview of systematic reviewsUmbrella reviewOpioidsInfectionsPreventionInterventions |
| spellingShingle | Irina Kudrina Svetlana Puzhko Kristian B. Filion Genevieve Gore Elena Paraskevopoulos Sarah Windle Marc O. Martel Mark J. Eisenberg Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews Systematic Reviews Overview of systematic reviews Umbrella review Opioids Infections Prevention Interventions |
| title | Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews |
| title_full | Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews |
| title_fullStr | Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews |
| title_full_unstemmed | Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews |
| title_short | Effectiveness of interventions for prevention of common infections in people who use opioids: a protocol for a systematic review of systematic reviews |
| title_sort | effectiveness of interventions for prevention of common infections in people who use opioids a protocol for a systematic review of systematic reviews |
| topic | Overview of systematic reviews Umbrella review Opioids Infections Prevention Interventions |
| url | https://doi.org/10.1186/s13643-021-01852-w |
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