Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia
<strong>Background:</strong> Meticulous examination of frozen section of cone specimens is required to precisely evaluate the resection margin status and rule out invasion in cases with high-grade cervical intraepithelial neoplasia (CIN). <strong>Objectives:</strong> The aim...
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| Format: | Article |
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Shiraz University of Medical Sciences
2015-10-01
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| Series: | Women’s Health Bulletin |
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| Online Access: | http://womenshealthbulletin.sums.ac.ir/article_45216_8b247c9a32c24419d0923c2011adbe36.pdf |
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| author | Tahereh Ashraf Ganjooei Zahra Vahedpoorfard Mitra Rafiezadeh Maliheh Arab Farah Farzaneh Maryam Sadat Hosseini Mehdi Yaseri |
| author_facet | Tahereh Ashraf Ganjooei Zahra Vahedpoorfard Mitra Rafiezadeh Maliheh Arab Farah Farzaneh Maryam Sadat Hosseini Mehdi Yaseri |
| author_sort | Tahereh Ashraf Ganjooei |
| collection | DOAJ |
| description | <strong>Background:</strong> Meticulous examination of frozen section of cone specimens is required to precisely evaluate the resection margin status and rule out invasion in cases with high-grade cervical intraepithelial neoplasia (CIN).
<strong>Objectives:</strong> The aim of the present study was to determine the role of frozen section examination (FSE) of the cone specimen in the evaluation of the resection margin status and to rule out invasion in patients with high-grade CIN.
<strong>Patients and Methods:</strong> This cross-sectional study was performed on 38 patients with high-grade CIN undergoing conization biopsy at Imam Hossein hospital in Tehran from April 2012 through May 2013. Then, FS examination was performed for all patients and the results obtained were compared with those of permanent paraffin sections.
<strong>Results:</strong> Thirty-three (86.8%) out of 38 patients had the same results in frozen and permanent sections of cone biopsy margin specimens (P = 1). Two out of 33 (6.1%) patients had frozen and permanent positive margins and 31 (93.9%) patients had negative frozen and permanent margins. Among the other 5 patients (13.2%), 2 had positive frozen margins and negative permanent margins and 3 patients had negative frozen margins and positive permanent margins. Diagnostic accuracies in cone margin and lesion grading were 63.1% and 44.7%, respectively.
<strong>Conclusions:</strong> In conclusion, in high-grade CIN, FS examination was a rapid, reliable and cost-effective means of evaluating cervical conization specimens. |
| first_indexed | 2024-12-11T01:32:30Z |
| format | Article |
| id | doaj.art-6057b94dc883462f8e9c13bd77410eae |
| institution | Directory Open Access Journal |
| issn | 2345-5136 2382-9990 |
| language | English |
| last_indexed | 2024-12-11T01:32:30Z |
| publishDate | 2015-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Women’s Health Bulletin |
| spelling | doaj.art-6057b94dc883462f8e9c13bd77410eae2022-12-22T01:25:19ZengShiraz University of Medical SciencesWomen’s Health Bulletin2345-51362382-99902015-10-01241510.17795/whb-2610545216Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial NeoplasiaTahereh Ashraf Ganjooei0Zahra Vahedpoorfard1Mitra Rafiezadeh2Maliheh Arab3Farah Farzaneh4Maryam Sadat Hosseini5Mehdi Yaseri6Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, IR IranDepartment of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, IR IranDepartment of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, IR IranDepartment of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, IR IranDepartment of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, IR IranDepartment of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, IR IranDepartment of Biostatistics, Tehran University of Medical Sciences, Tehran, IR Iran<strong>Background:</strong> Meticulous examination of frozen section of cone specimens is required to precisely evaluate the resection margin status and rule out invasion in cases with high-grade cervical intraepithelial neoplasia (CIN). <strong>Objectives:</strong> The aim of the present study was to determine the role of frozen section examination (FSE) of the cone specimen in the evaluation of the resection margin status and to rule out invasion in patients with high-grade CIN. <strong>Patients and Methods:</strong> This cross-sectional study was performed on 38 patients with high-grade CIN undergoing conization biopsy at Imam Hossein hospital in Tehran from April 2012 through May 2013. Then, FS examination was performed for all patients and the results obtained were compared with those of permanent paraffin sections. <strong>Results:</strong> Thirty-three (86.8%) out of 38 patients had the same results in frozen and permanent sections of cone biopsy margin specimens (P = 1). Two out of 33 (6.1%) patients had frozen and permanent positive margins and 31 (93.9%) patients had negative frozen and permanent margins. Among the other 5 patients (13.2%), 2 had positive frozen margins and negative permanent margins and 3 patients had negative frozen margins and positive permanent margins. Diagnostic accuracies in cone margin and lesion grading were 63.1% and 44.7%, respectively. <strong>Conclusions:</strong> In conclusion, in high-grade CIN, FS examination was a rapid, reliable and cost-effective means of evaluating cervical conization specimens.http://womenshealthbulletin.sums.ac.ir/article_45216_8b247c9a32c24419d0923c2011adbe36.pdfconizationfrozen sectionshighgrade intraepithelial neoplasia |
| spellingShingle | Tahereh Ashraf Ganjooei Zahra Vahedpoorfard Mitra Rafiezadeh Maliheh Arab Farah Farzaneh Maryam Sadat Hosseini Mehdi Yaseri Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia Women’s Health Bulletin conization frozen sections high grade intraepithelial neoplasia |
| title | Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia |
| title_full | Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia |
| title_fullStr | Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia |
| title_full_unstemmed | Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia |
| title_short | Frozen Section Evaluation of the Cone Margin Status in High-Grade Cervical Intraepithelial Neoplasia |
| title_sort | frozen section evaluation of the cone margin status in high grade cervical intraepithelial neoplasia |
| topic | conization frozen sections high grade intraepithelial neoplasia |
| url | http://womenshealthbulletin.sums.ac.ir/article_45216_8b247c9a32c24419d0923c2011adbe36.pdf |
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